Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:11/30/-0001
Start Date:October 2010
End Date:December 2013
Contact:Pfizer CT.gov Call Center
Phone:1-800-718-1021

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An Exploratory Phase 2, Randomized, Double-Blind, Multicenter Study To Assess The Effects Of Tofacitinib (CP-690,550) On Magnetic Resonance Imaging Endpoints, In Methotrexate Naïve Subjects With Early Active Rheumatoid Arthritis


Evaluation of efficacy and safety of tofacitinib (CP-690,550) for the treatment of early
rheumatoid arthritis in adult patients with moderate to severe disease who are methotrexate
naïve. The efficacy will be evaluated by exploring the effects on joint structure assessed
by magnetic resonance imaging, x-rays and by standard clinical assessment.


Inclusion Criteria:

- Adult patients with moderate to severe early rheumatoid arthritis (< 2 years) who are
methotrexate and biologic disease modifying antirheumatic drug naive.

Exclusion Criteria:

- Pregnant or lactating patients;

- Patients with renal or hepatic impairment or other severe or progressing disease;

- Patients with contraindication to magnetic resonance imaging with gadolinium
contrast.
We found this trial at
10
sites
Oklahoma City, Oklahoma 73104
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Allen, TX
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Daytona Beach, Florida 32114
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Daytona Beach, FL
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Gilbert, Arizona 85234
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Gilbert, AZ
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Huntington Beach, California 92646
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Huntington Beach, CA
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Largo, Florida 33771
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Largo, FL
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Ormond Beach, Florida 32174
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Ormond Beach, FL
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Pinellas Park, Florida 33782
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Pinellas Park, FL
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St. Petersburg, Florida 33710
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St. Petersburg, FL
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Upland, CA
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