Diagnostic Innovations in Glaucoma Study
| Status: | Recruiting |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | April 1995 |
| End Date: | July 2016 |
| Contact: | Eunice Williams-Steppe, MA |
| Email: | ewsteppe@glaucoma.ucsd.edu |
| Phone: | 858-822-1133 |
A prospective, longitudinal observational cohort study evaluating the relationship between
changes in the structure of the eye and the vision loss caused by glaucoma. There are two
main parts to the study: 1) Visual Function and 2) Optic Nerve Structure
changes in the structure of the eye and the vision loss caused by glaucoma. There are two
main parts to the study: 1) Visual Function and 2) Optic Nerve Structure
The purpose of the study is:
1. To further determine the nature of vision loss and optic nerve structural change
associated with glaucoma. Using recently developed psychophysical and imaging
techniques, we will continue use of a multivariate approach for analysis of the
functional and structural changes associated with glaucoma to delineate further the
relationship of these changes to the underlying physiological mechanisms associated
with magnocellular, small bistratified "blue-yellow", and parvocellular neural
pathways.
2. To evaluate and improve new diagnostic and monitoring techniques encompassing measures
of visual function and optic nerve and retina nerve fiber layer structure and to
compare the rate and patterns of progression of glaucomatous damage
3. To improve techniques for evaluation of current management and new therapies for
glaucoma as they become available. We will expand our analysis using multivariate
techniques incorporating visual function, optic nerve structure, and various risk
factors to improve detection of true change.
4. To determine the quantitative temporal relationships between recognizable optic nerve
damage and measurable visual field loss. Using new techniques with improved
sensitivity, the detection and monitoring of early optic disc defects may provide
profiles of people at risk for developing glaucomatous visual function loss thus better
defining target populations for treatment.
SPECIFIC AIMS OF DIGS: STRUCTURAL ASSESSMENT Overall Aim: Develop improved methods to 1)
detect the onset and progression of structural damage due to glaucoma, and 2) to measure the
rate of glaucomatous progression and its determinants, and 3) characterize the relationship
between structural and functional change over time. In addition, a major goal of this
research is to develop methods to shorten the time frame needed to identify and verify
progression of optic disc and retinal nerve fiber damage.
SPECIFIC AIMS OF DIGS: VISUAL FUNCTION Overall Aim: Develop improved measures to detect the
onset and progression of glaucoma, to assess treatment effectiveness, and to validate
predictive genetic testing using psychophysical measures of visual function.
1. To further determine the nature of vision loss and optic nerve structural change
associated with glaucoma. Using recently developed psychophysical and imaging
techniques, we will continue use of a multivariate approach for analysis of the
functional and structural changes associated with glaucoma to delineate further the
relationship of these changes to the underlying physiological mechanisms associated
with magnocellular, small bistratified "blue-yellow", and parvocellular neural
pathways.
2. To evaluate and improve new diagnostic and monitoring techniques encompassing measures
of visual function and optic nerve and retina nerve fiber layer structure and to
compare the rate and patterns of progression of glaucomatous damage
3. To improve techniques for evaluation of current management and new therapies for
glaucoma as they become available. We will expand our analysis using multivariate
techniques incorporating visual function, optic nerve structure, and various risk
factors to improve detection of true change.
4. To determine the quantitative temporal relationships between recognizable optic nerve
damage and measurable visual field loss. Using new techniques with improved
sensitivity, the detection and monitoring of early optic disc defects may provide
profiles of people at risk for developing glaucomatous visual function loss thus better
defining target populations for treatment.
SPECIFIC AIMS OF DIGS: STRUCTURAL ASSESSMENT Overall Aim: Develop improved methods to 1)
detect the onset and progression of structural damage due to glaucoma, and 2) to measure the
rate of glaucomatous progression and its determinants, and 3) characterize the relationship
between structural and functional change over time. In addition, a major goal of this
research is to develop methods to shorten the time frame needed to identify and verify
progression of optic disc and retinal nerve fiber damage.
SPECIFIC AIMS OF DIGS: VISUAL FUNCTION Overall Aim: Develop improved measures to detect the
onset and progression of glaucoma, to assess treatment effectiveness, and to validate
predictive genetic testing using psychophysical measures of visual function.
Inclusion Criteria:
- Open angles
- Best-corrected acuity of 20/40 or better
- Spherical refraction within + 5.0 D, and cylinder within + 3.0 D with plus OR minus
cylinders
- ≥ 18 years old
- A family history of glaucoma is allowed
- Ability for study to acquire adequate or better quality stereophotographs
- Ability to do reliable standard Humphrey 30-2 or 24-2 visual fields
- Participants with glaucoma or at risk for glaucoma or healthy controls
Exclusion Criteria:
- History of intraocular surgery (except for uncomplicated cataract surgery)
- Non-glaucomatous secondary causes of elevated IOP (e.g. iridocyclitis, trauma)
- Other intraocular eye disease
- Other diseases affecting visual field (e.g. pituitary lesions, demyelinating
diseases, HIV+ or AIDS, or diabetic retinopathy), with medications known to affect
visual field sensitivity
- Problems other than glaucoma affecting color vision.
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