Study to Evaluate GSK Biologicals' Herpes Zoster Vaccine GSK1437173A in Human Immunodeficiency Virus (HIV)-Infected Subjects

Inclusion Criteria:

- Subjects who the investigator believes that they can and will comply with the
requirements of the protocol;

- Male and female subjects at least 18 years old at the time of vaccination;

- Subjects born before 1985 and not from a tropical region. Subjects born in 1985 or
later and subjects born before 1985 in tropical regions must have a history of
Varicella Zoster virus (VZV) infection or serological evidence of prior VZV infection;

- Written informed consent obtained from the subject;

- Female subjects of non-childbearing potential may be enrolled in the study;
Non-childbearing potential is defined as current tubal ligation, hysterectomy,
ovariectomy or post-menopause.

OR Female subjects of childbearing potential may be enrolled in the study, if the subject
has practiced adequate contraception for 30 days prior to vaccination, and has a negative
pregnancy test on the day of vaccination, and has agreed to continue adequate contraception
during the entire treatment period and for 2 months after completion of the vaccination
series;

- Known to be human immunodeficiency virus-1 (HIV-1) infected, diagnosed at least 1 year
prior to enrolment;

- For the antiretroviral therapyART High CD4 and ART Low CD4 cohorts:

- Stable on ART for at least one year

- CD4 T cell count >= 50 cells /mm3 at screening

- Undetectable VL at screening;

- For the non-ART High CD4 cohort:

- ART-naïve subjects who have never received anti-retroviral therapy after HIV
diagnosis and for whom commencement of ART is not expected based on current
assessment within next seven months;

- HIV VL >= 1000 copies/mL and <= 100 000 copies/mL at screening

- CD4 T cell count >= 500 cells/mm3 at screening.

Exclusion Criteria:

- Use of any investigational or non-registered product other than the study vaccine
within 30 days preceding the first dose of study vaccine, or planned use during the
study period;

- Vaccination against varicella or herpes zoster (HZ) within the previous 12 months;

- Occurrence of a varicella or HZ episode within the previous 12 months;

- History of allergic disease or reactions likely to be exacerbated by any component of
the vaccine. Additionally, consider allergic reactions to other material or equipment
related to study participation. Please note, the vaccine and vials in this study do
not contain latex;

- Has currently an Acquired Immunodeficiency Syndrome (AIDS) defining condition;

- Opportunistic infection or AIDS-associated malignancy in the previous year;

- Any confirmed or suspected immunosuppressive or immunodeficient condition resulting
from disease other than HIV infection or immunosuppressive/cytotoxic therapy;

- Administration of immunoglobulins, and/or any blood products within 90 days preceding
the first dose of study vaccine/placebo or planned administration during the study
period;

- Chronic administration of immunosuppressive or other immune-modifying drugs within 6
months prior to the first vaccine dose;

- Administration and/or planned administration of a vaccine not foreseen by the study
protocol within 30 days before dose 1, dose 2 and/or 3 of vaccine and/or within 30
days after any dose. However, licensed non-replicating vaccines may be administered up
to 8 days prior to dose 1, 2 and/or 3, and/or at least 14 days after any dose of study
vaccine;

- Concurrently participating in another clinical study, at any time during the study
period, in which the subject has been or will be exposed to an investigational or a
non-investigational product;

- Acute disease at the time of enrolment;

- Any contraindication to receiving intramuscular injections;

- Any condition or illness which might interfere with the evaluation of the safety or
immunogenicity of the vaccine;

- Active hepatitis B (HBV) infection or active hepatitis C (HCV) infection.

- Current use of HIV fusion inhibitors, chemokine (C-C motif) receptor (CCR5) inhibitors
or Interleukin-2/ Interleukin-7/ Interferon;

- For subjects in the ART cohorts, any change in anti-retroviral drug regimen within 12
weeks prior to vaccination;

- Pregnant or lactating female;

- Female planning to become pregnant or planning to discontinue contraceptive
precautions;

- Abnormal biochemical and hematological laboratory values obtained for blood samples
collected at screening.