Exercise Study Including Patients With Hypertrophic Cardiomyopathy
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Orthopedic |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/2/2016 |
| Start Date: | May 2010 |
| End Date: | April 2012 |
| Contact: | Lisa Garrett |
| Email: | lisamariegarrett@gmail.com |
| Phone: | (650) 736-7878 |
A Randomized Trial of Moderate Intensity Exercise Training in Patients With Hypertrophic Cardiomyopathy
The long term health and cardiovascular benefits of a regular exercise program have been
well-established. National guidelines recommend involvement in moderate aerobic fitness
(i.e. walking, bicycling, light jogging, swimming) for patients with hypertrophic
cardiomyopathy (HCM). However, data on potential benefits of recreational exercise, useful
parameters for risk stratification, and methods of devising individual exercise
prescriptions are completely lacking. The specific aims of this study are: 1) to devise a
safe moderate intensity exercise training program in patients with HCM, and 2) to determine
whether exercise training improves ability to perform activities and tasks, heart size and
function, and quality of life in patients with HCM.
well-established. National guidelines recommend involvement in moderate aerobic fitness
(i.e. walking, bicycling, light jogging, swimming) for patients with hypertrophic
cardiomyopathy (HCM). However, data on potential benefits of recreational exercise, useful
parameters for risk stratification, and methods of devising individual exercise
prescriptions are completely lacking. The specific aims of this study are: 1) to devise a
safe moderate intensity exercise training program in patients with HCM, and 2) to determine
whether exercise training improves ability to perform activities and tasks, heart size and
function, and quality of life in patients with HCM.
Inclusion Criteria:
1. Ages 18 - 80 years old.
2. Diagnosis of hypertrophic cardiomyopathy, defined by the presence of unexplained
left-ventricular hypertrophy (wall thickening) > 13 mm in any wall segment.
3. Exercise £ 30 minutes, 1 day per week for the previous 3 months.
4. Agreement to be a participant in the study protocol and willing/able to return for
follow-up.
Exclusion Criteria:
1. History of exercise-induced syncope or arrhythmias (ventricular tachycardia or
non-sustained ventricular tachycardia).
2. Medically refractory LV outflow tract obstruction being evaluated for septal
reduction therapy.
3. Less than 3 months post septal reduction therapy (surgery or catheter based
intervention).
4. Hypotensive response to exercise (> 20 mmHg drop in systolic blood pressure from peak
blood pressure to post exercise blood pressure).
5. Pregnancy.
6. ICD placement in last 3 months or scheduled.
7. Life expectancy less than 12 months.
8. Inability to exercise due to orthopedic or other non-cardiovascular limitations.
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Stanford University School of Medicine Vast in both its physical scale and its impact on...
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