Development of a Bedside Pain Assessment Kit for Postherpetic Neuralgia

We hypothesize: (a) that a Bedside Sensory Testing Kit for PHN can be designed such that it
works efficiently with Subjects and Investigators, is tolerated well by Subjects, and is
statistically reliable between Investigators; (b) that the sensory testing kit can
distinguish between PHN patients with different sensory qualities to their pain which may be
caused by different underlying pain mechanisms.

The subjects will be patients with postherpetic neuralgia who voluntarily participate and
meet eligibility criteria. The study participants will complete a brief questionnaire and
undergo three rounds of the BSTK, performed by two study investigators. The items in the
BSTK correspond to a series of sensory assessments, each of which are aimed to contribute to
the characterization of individuals' PHN pain.

Inclusion Criteria:

- Subject is between 40 and 85 years old.

- Physician documentation of history of postherpetic neuralgia must be provided; pain
persisting more than 3 months/90 days after a patient's vesicular rash (shingles) has
healed.

- Subject is able to speak, read and write in English and comply with all study
procedures;

- Subject is willing to voluntarily sign and date an Informed Consent Form, approved by
an IRB, prior to the conduct of any study-specific procedures;

- Subject must be willing to abstain from PRN (as needed) pain medicine for 12 hours
prior to the study but may continue their standing doses of pain medicine.

Exclusion Criteria:

- Subject is pregnant and/or breast-feeding.

- Subjects with additional sources of chronic pain will not be allowed if the severity
of pain in additional locations is severe enough to compromise assessment of PHN
pain. This will be left to the Investigator's discretion.

- Subject has a medical condition, other than PHN, that is not well-controlled with
treatment; or the subject has any clinically significant condition that would, in the
opinion of the investigator, preclude study participation, interfere with the
assessment of pain, or pose unacceptable risk to the participant.

- Subject has been enrolled in another study within 30 days.

- Subject has a known contact allergy to surgical skin markers.

- In the judgment of the investigator, the subject has a psychiatric or psychological
disorder that would interfere with the completion of the study, confound the study
results, or pose patient risk.

- Subject has neuropathy or nerve fiber disease other than PHN (e.g., diabetic
peripheral neuropathy).