Bivalent Norovirus Vaccine Study

Inclusion Criteria:

Participants must meet all of the inclusion criteria listed below:

1. Signed written informed consent.

2. Age:

- Cohort A: 18-49 years, inclusive

- Cohort B: 50-64 years, inclusive

- Cohort C: 65-85 years, inclusive

- Cohort D: 18-49 years, inclusive

3. Health Status:

- Cohort A and D: In good health as determined by a screening evaluation that
includes vital signs, medical history, and physical exam within 45 days before
administration of IM Norovirus Bivalent VLP Vaccine or control.

- Cohorts B and C: In good health as determined by a screening evaluation that
includes vital signs, medical history, and physical exam within 45 days before
administration of IM Norovirus Bivalent VLP Vaccine or control. Any existing
medical diagnoses or conditions must be stable based on medical history and
targeted physical examination. A stable medical condition is defined as: (A)
Clinically acceptable health outcomes for the specific condition over the prior 6
months and (B) No change in prescription medication(s), dose, or frequency over
the prior 3 months. Acceptable changes in medications are: a change of health
care provider or insurance company or that is made for financial reasons as long
as the medications are in the same class and/or a change due to improvement in a
disease outcome.

4. Expressed interest and availability to fulfill the study requirements.

5. Female participants must be of non-childbearing potential (surgically sterile or
post-menopausal for greater than or equal to [>=] 12 months), or if of childbearing
potential (as determined by the investigator) must be practicing abstinence or using
an effective licensed method of birth control (example oral contraceptives; diaphragm
or condom in combination with contraceptive jelly, cream, or foam; intrauterine
contraceptive device, or Depo-Provera; skin patch; vaginal ring or cervical cap) for
30 days prior to vaccination and must agree to continue such precautions for at least
60 days after the last vaccination. A woman is eligible if she is monogamous with a
male who has had a vasectomy. Male participants must agree not to father a child for
at least 60 days after the last vaccination and to practice abstinence or use an
effective method of birth control as noted above.

6. Agrees not to participate in another clinical trial with an investigational product
for the entire duration of the study one year after the last study dose that is 393
days.

7. Agrees to storage of unused clinical specimens for an indefinite period of time for
future norovirus research or research on other gastrointestinal pathogens.

Exclusion Criteria:

Participants who meet any of the exclusion criteria at baseline will be excluded from study
participation. The exclusion criteria are:

1. History of any of the following medical illnesses:

- Diabetes

- Cancer (malignancy other than resolved/excised skin lesion)

- Heart disease (hospitalization for a heart attack, arrhythmia, or syncope)

- Unconsciousness (other than a single brief "concussion")

- Seizures (other than febrile seizures as a child less than [<] 5 years old)

- Recurrent infections (more than 3 hospitalizations for invasive bacterial
infections such as pneumonia or meningitis)

- Any condition associated with immunodeficiency or participants taking
immunosuppressant medication

- Neuroinflamatory or auto-immune disease

2. Any current illness requiring daily medication other than the following:

- Cohort A and D: Vitamins, birth control, anti-hypertensive medication,
antihistamines or anti-depressant medication. The Principal Investigator (PI)
should consult with the Central Safety Monitor and/or the sponsor for any
clarification of medications allowable.

- Cohorts B and C: Vitamins, birth control, anti-hypertensive medication,
antihistamines or anti-depressant medication or any current illness requiring
daily medication other than as noted above in inclusion criteria 3. The PI should
consult with the Central Safety Monitor and/or the sponsor for any clarification
of medications allowable.

3. Allergies or hypersensitivity to any component of the vaccine including MPL and
Al(OH)3 adjuvants.

4. Any clinically significant abnormality detected on physical examination, including:

- Murmur (other than a functional murmur)

- Focal neurological abnormality

- Hepatosplenomegaly

- Lymphadenopathy

- Jaundice

5. Hypertension (Blood Pressure [BP] greater than [>] 140/90 millimeter of mercury [mm
Hg] on two separate days)

6. Any lab abnormality (per the site local laboratory), as listed below:

- Absolute Neutrophil Count (ANC) outside the normal range (may be repeated if
outside this limit)

- Total white blood cells (WBC) outside the normal range (may be repeated if
outside this limit)

- Hemoglobin outside the normal range (may be repeated if outside this limit)

- Platelet count outside the normal range (may be repeated if outside this limit)

- Blood urea nitrogen (BUN) > upper limit of normal (ULN) (may be repeated if
outside this limit)

- Creatinine > ULN (may be repeated if outside this limit)

- Glucose (fasting or random) outside the normal range (may be repeated if outside
this limit)

- Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) > ULN (may be
repeated if outside this limit)

7. Positive serology for hepatitis C or Human Immunodeficiency Virus (HIV) antibody or
hepatitis B surface antigen.

8. For women of child bearing potential, positive serum pregnancy test within 14 days and
urine pregnancy test within 24 hours of administering either dose of IM Norovirus
Bivalent VLP Vaccine or control.

9. Nursing mother.

10. Temperature >100.4 degree Fahrenheit (F) or symptoms of an acute self-limited illness
such as an upper respiratory infection or gastroenteritis within 3 days of
administration of IM Norovirus Bivalent VLP Vaccine or control.

11. Previous participation in a Norovirus vaccine or challenge study.

12. Study site personnel or their family members.

13. Significant history of psychiatric hospitalization, alcohol abuse, or illicit drug use
in the prior 5 years.

14. Completion of an investigational vaccine or drug study within 28 days before
administration of IM Norovirus Bivalent VLP Vaccine or control.

15. Have a history of receiving immunoglobulin or other blood product within the 3 months
prior to vaccination in this study.

16. Other condition that in the clinical judgment of the investigator would jeopardize the
safety or rights of a participant participating in the trial, would render the
participant unable to comply with the protocol or would interfere with the evaluation
of the vaccine.