Impact of Race/Ethnicity on Platelet Function

Inclusion Criteria: Each subject must fulfill the following criteria in order to be
included in the study.

- The subject must be capable of understanding the nature of the study and executing an
informed consent document.

- The subject must be aged 19 years or older.

- For healthy subjects, the subject must deny taking any medications that affect
platelet function for at least 7 days before blood collection.

- For diseased patients, subjects with documented CAD are eligible to participate if
they have been treated with antiplatelet therapy of aspirin (81 to 325 mg/day) with
and without clopidogrel (75 mg/day) or another P2Y12 antagonist for at least one
month.

Exclusion Criteria: For healthy volunteers, subjects who fulfill one or more of the
following criteria will be excluded from the study.

- taking medications for chronic cardiovascular diseases.

- illnesses requiring hospitalization or surgery within the last three months.

- history of drug or alcohol abuse.

- history of recent anemia or thrombocytopenia.

- history of excessive bleeding or thrombosis.

- pregnancy.

For coronary heart disease subjects, subjects who fulfill one or more of the following
criteria will be excluded from the study.

- illnesses requiring hospitalization or surgery within the last one month.

- history of drug or alcohol abuse.

- history of recent anemia or thrombocytopenia.

- pregnancy.

- recent bleeding diathesis

- malignancy

- renal insufficiency

- liver dysfunction

- treatment with warfarin or glycoprotein (GP) IIb/IIIa antagonists during the
preceding 14 days