Johns Hopkins Crohn's Disease and Ulcerative Colitis Study
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Colitis, Irritable Bowel Syndrome (IBS), Gastrointestinal, Crohns Disease |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 5 - Any |
| Updated: | 8/22/2018 |
| Start Date: | July 1996 |
| End Date: | December 2020 |
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC),
is a idiopathic, chronic and frequently disabling inflammatory disorder of the intestines
characterized by a dysregulated mucosal immune response that affect more than a million
Americans. This current protocol was established in 1996 with the goal of identifying the
genetic and environmental components that contribute to the development of IBD, especially in
families.
is a idiopathic, chronic and frequently disabling inflammatory disorder of the intestines
characterized by a dysregulated mucosal immune response that affect more than a million
Americans. This current protocol was established in 1996 with the goal of identifying the
genetic and environmental components that contribute to the development of IBD, especially in
families.
We initiated this research study in 1996 with the overall goal of identifying IBD
susceptibility genes. In the beginning, our major focus was recruitment of multiply affected
IBD pedigrees for linkage studies, but we have since expanded our study to include singleton
cases and spousal/friend as well as population controls for comparison purposes Our
recruitment goal is 2500 subjects.
Blood samples obtained from participants are used to isolate lymphocytes for storage, serum
for serological analysis of antibodies and other proteins relevant to IBD and DNA for
genotyping or sequencing. Lymphocytes may be transformed with EBV to establish immortalized
lymphoblastoid cell lines. These cell lines can be used as a secondary DNA source or to study
IBD relevant gene, protein expression and cell function
susceptibility genes. In the beginning, our major focus was recruitment of multiply affected
IBD pedigrees for linkage studies, but we have since expanded our study to include singleton
cases and spousal/friend as well as population controls for comparison purposes Our
recruitment goal is 2500 subjects.
Blood samples obtained from participants are used to isolate lymphocytes for storage, serum
for serological analysis of antibodies and other proteins relevant to IBD and DNA for
genotyping or sequencing. Lymphocytes may be transformed with EBV to establish immortalized
lymphoblastoid cell lines. These cell lines can be used as a secondary DNA source or to study
IBD relevant gene, protein expression and cell function
Inclusion Criteria:
ADULTS:
- Patients with IBD and their family members who have or do not have IBD.
- People that do not have IBD nor have a family member with IBD needed for comparison
purposes.
CHILDREN:
- Children age 5 or older with IBD and their family members who have or do not have IBD.
- Children that do not have IBD nor have a family member with IBD needed for comparison
purposes.
Exclusion Criteria:
- The only exclusions are age parameters and health reasons that would preclude their
enrollment; such as, for anemic patients. Blood-draws on anemic patients may, in
certain medical cases, pose a health risk to them; therefore, we request that if they
are anemic that they present a letter from their personal physician giving explicit
permission for them to join if at the time it is clinically advisable.
We found this trial at
1
site
3400 N Charles St
Baltimore, Maryland 21205
Baltimore, Maryland 21205
410-516-8000
Principal Investigator: Florin Selaru, M.D.
Phone: 410-614-3816
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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