Regulation of Endothelial Progenitor Cells by Short-Term Exercise
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies, Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | 50 - 80 |
| Updated: | 7/13/2018 |
| Start Date: | July 2011 |
| End Date: | November 2020 |
Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are
important for maintaining cardiovascular health. The prevalence of cardiovascular disease in
older adults is associated with reduced circulating EPC numbers. Studies have shown reduced
EPC number and function in old vs. young individuals, and endurance exercise training
increases EPC number and function in young adults. Oxidative stress adversely affects
endothelial cells and preliminary evidence indicates that oxidative stress negatively affects
EPC function. Conversely, regular exercise reduces markers of oxidative stress and may
enhance EPC function in older adults. The investigators hypothesize that older
endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC
function and that altering the physical activity levels of both groups will move them to
intermediate points between these two extremes. The investigators also propose that the
investigators can "mimic" the effect of exercise training on EPC function in cell culture by
altering intracellular levels of a key enzyme and a signaling molecule which the
investigators have shown to regulate EPC function with respect to exercise training in young
individuals.
important for maintaining cardiovascular health. The prevalence of cardiovascular disease in
older adults is associated with reduced circulating EPC numbers. Studies have shown reduced
EPC number and function in old vs. young individuals, and endurance exercise training
increases EPC number and function in young adults. Oxidative stress adversely affects
endothelial cells and preliminary evidence indicates that oxidative stress negatively affects
EPC function. Conversely, regular exercise reduces markers of oxidative stress and may
enhance EPC function in older adults. The investigators hypothesize that older
endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC
function and that altering the physical activity levels of both groups will move them to
intermediate points between these two extremes. The investigators also propose that the
investigators can "mimic" the effect of exercise training on EPC function in cell culture by
altering intracellular levels of a key enzyme and a signaling molecule which the
investigators have shown to regulate EPC function with respect to exercise training in young
individuals.
Inclusion Criteria:
- 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal
Exclusion Criteria:
- history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver
disease, HIV; uncontrolled hyperlipidemia/hypertension
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