An Inpatient Study Of The Efficacy, Safety, And Tolerability Of PF-02545920 In The Treatment Of Acute Exacerbation Of Schizophrenia



Status:Completed
Conditions:Schizophrenia
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 65
Updated:5/24/2018
Start Date:October 2010
End Date:August 2011

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A Phase 2, Multicenter, Double-blind, Randomized, Parallel Group, 4-week Inpatient Study To Evaluate The Safety And Efficacy Of Two Fixed Doses Of Pf-02545920 Compared To Placebo In The Treatment Of Acute Exacerbation Of Schizophrenia Using Risperidone As An Active Control

This study aims to evaluate whether PF-02545920 is safe and effective in the treatment of
acute exacerbation of schizophrenia during a 4-week inpatient treatment period. The study
will use the Positive and Negative Syndrome Scale (PANSS) to measure change in symptoms for
PF-02545920 compared to risperidone and placebo treatment.


Inclusion Criteria:

- Diagnosis of schizophrenia with acute exacerbation of illness

- The current acute exacerbation of schizophrenia must be less than 4 weeks duration
prior to the initial evaluation.

Exclusion Criteria:

- Subjects with evidence or history of clinically significant uncontrolled medical
illness

- Subjects with a current diagnosis of schizoaffective disorder, major depression,
bipolar disorder, or obsessive compulsive disorder.

- Subjects who meet Diagnostic and Statistical Manual-IV (DSM-IV)defined diagnostic
criteria for psychoactive substance dependence (excluding nicotine dependence) within
12 months of screening or DSM-IV defined substance abuse within 3 months prior to
screening.
We found this trial at
39
sites
Kirkland, Washington 98033
2000
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Kirkland, WA
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Anaheim, California 92801
1960
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Anaheim, CA
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811 Juniper St NE
Atlanta, Georgia 30308
(404) 881-5800
Atlanta Center for Medical Research Welcome to the Atlanta Center for Medical Research, a leader...
434
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Atlanta, GA
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Austin, Texas 78731
1062
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from 43215
Austin, TX
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Austin, Texas 78745
1065
mi
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Austin, TX
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Austin, Texas 78754
1057
mi
from 43215
Austin, TX
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8043 Cooper Creek Boulevard Suite 107
Bradenton, Florida 34201
(941) 747-7900
Florida Clinical Research Center, LLC Led by Andrew J. Cutler, M.D., Florida Clinical Research Center,...
862
mi
from 43215
Bradenton, FL
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DeSoto, Texas 75115
921
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DeSoto, TX
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Escondido, California 92025
1937
mi
from 43215
Escondido, CA
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Escondido, California 92025
1935
mi
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Escondido, CA
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Garden Grove, California 92845
1967
mi
from 43215
Garden Grove, CA
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Hoffman Estates, Illinois 60169
302
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Hoffman Estates, IL
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Hoffman Estates, Illinois 60169
302
mi
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Hoffman Estates, IL
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1786 Moon Lake Boulevard
Hoffman Estates, Illinois 60169
303
mi
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Hoffman Estates, IL
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88 Park Avenue
Hollis, New York 11423
470
mi
from 43215
Hollis, NY
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Houston, Texas 77024
996
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Houston, TX
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5314 Dashwood Drive
Houston, Texas 77081
998
mi
from 43215
Houston, TX
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10200 Northeast 132nd Street
Kirkland, Washington 98034
2001
mi
from 43215
Kirkland, WA
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Lake Charles, Louisiana 70601
885
mi
from 43215
Lake Charles, LA
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Lake Charles, Louisiana 70601
884
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Lake Charles, LA
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Little Rock, Arkansas 72201
622
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Little Rock, AR
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Long Beach, California 90806
1976
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Long Beach, CA
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Long Beach, California 90822
1972
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Long Beach, CA
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Maitland, Florida 32751
788
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Maitland, FL
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4256
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Mannheim,
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101 The City Drive South
Orange, California 92868
714-456-7890
University of California, Irvine Medical Center We are UC Irvine Health. We are a devoted...
1958
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Orange, CA
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434 West Kennedy Boulevard
Orlando, Florida 32810
789
mi
from 43215
Orlando, FL
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Paramount, California 90723
1971
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from 43215
Paramount, CA
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8835 Vans Street
Paramount, California 90723
1971
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Paramount, CA
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Philadelphia, Pennsylvania 19139
412
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Philadelphia, PA
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Rockville, Maryland 20850
318
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Rockville, MD
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10330 Old Olive Street Road
Saint Louis, Missouri 63141
404
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Saint Louis, MO
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San Diego, California 92123
1947
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San Diego, CA
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1960
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Santa Ana, CA
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Torrance, California 90502
1980
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Torrance, CA
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Torrance, California 90505
1983
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Torrance, CA
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Washington, District of Columbia 20016
324
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Washington,
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Willingboro, New Jersey 08046
430
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Willingboro, NJ
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218 Sunset Road
Willingboro, New Jersey 08046
430
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Willingboro, NJ
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