Stress, Hormones, and Eating



Status:Archived
Conditions:Food Studies, Psychiatric
Therapuetic Areas:Pharmacology / Toxicology, Psychiatry / Psychology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:July 2010
End Date:December 2011

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Novel Interventions to Reduce Stress Induced Non-homeostatic Eating


The investigators will develop a measure of endogenous opioid tone that might serve as a
biological marker for drive for palatable food. Using a 'naltrexone probe,' the
investigators will assess whether individual response to one dose of an opioid receptor
antagonist, naltrexone, is related to non-homeostatic eating in non-pregnant women.

Hypothesis 1: Naltrexone Response will be related to non-homeostatic eating.

Hypothesis 2: Response profiles to the 25 mg dose will be slightly less in magnitude than
the 50 mg dose. However, responses will be similarly related to non-homeostatic eating
measures.

Hypothesis 3: Response to naltrexone will be highly stable within individuals across time,
in the absence of an intervention.



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San Francisco, California 94118
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