Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes



Status:Active, not recruiting
Conditions:Endocrine, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:50 - 80
Updated:7/13/2018
Start Date:July 2011
End Date:September 2021

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Trial Summary
Trial Overview
Inclusion Criteria

Exercise Training, CACs, and Vascular Function in Older Veterans With IGT (Impaired Glucose Tolerance)

The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the
cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant
impact on the millions of Americans who have T2DM. This project is designed to 1) determine
the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those
with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic
exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether
improvement in EPC number and function translates to improved endothelial function, increased
capillarization, and improved glucose metabolism in T2DM.


Inclusion Criteria:

- Age 50-80

- Non-smoker

- If woman, postmenopausal >1 year

Exclusion Criteria:

- History of heart disease or stroke

- Cancer

- Poorly controlled hypertension or dyslipidemia

- Kidney or Liver diseases
We found this trial at
1
site
Baltimore VA Medical Center
Baltimore, Maryland 21201
Principal Investigator: Steven J Prior, Ph.D.
Phone: 410-605-7000
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mi
from
Baltimore, MD
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