Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

Initially, patients will be treated with oral CC-223 for one month. During this time, various
tests (involving blood and urine collections, ECGs, etc) will be performed. Those whose
tumors stabilize or regress may continue receiving treatment for as long as they benefit from
CC-223. Different dose levels of CC-223 will be tested in a dose-rising study design.

Inclusion Criteria:

- Histologically-confirmed advanced solid tumor, Non-Hodgkin Lymphoma or multiple
myeloma

- Patients have not tolerated or progressed on standard therapy, and no further standard
therapy is available

- Archival and screening tumor biopsy

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1 (solid tumors), 0-2
(hematologic malignancy)

- Adequate organ function

Exclusion Criteria:

- Prior systemic cancer-directed treatments or investigational drugs within 4 weeks or 5
half lives, whichever is shorter, prior to starting study drug or who have not
recovered from side effects of such therapy. Subjects must have recovered from any
effects of recent radiotherapy that might confound the safety evaluation of study drug

- Symptomatic brain metastases (prior Rx and stable metastases are OK)

- Acute or chronic liver or renal disease or pancreatitis

- Diarrhea ≥ Grade 2, impaired GI absorption

- Impaired cardiac function

- Diabetes requiring Rx, glucose >126 mg/dL, HbA1c ≥6.5%

- Peripheral neuropathy ≥ Grade 2

- Pulmonary fibrosis

- Known HIV infection

- Known chronic hepatitis B or C virus (HBV/HCV) infection, unless comorbidity in
subjects with HCC

- Pregnant, inadequate contraception

- Most concurrent second malignancies