Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents

Autism spectrum disorders (ASD) affect approximately 1 out of 150 children and adolescents
in the United States, making them one of the most common neurobiological conditions.
Comorbid anxiety disorders affect as many as 80% of youth with ASD, causing substantial
distress and impairment over and above that caused by an ASD diagnosis alone. While
cognitive-behavioral therapy (CBT) has been established as the gold standard treatment for
anxiety disorders among typically developing youth, a protocol does not exist for early
adolescents with ASD and comorbid anxiety disorders. Accordingly, we are proposing to
develop a CBT protocol for anxiety and comorbid ASD in early adolescence.

Initial protocol development efforts will focus on adapting relevant treatment elements from
an effective CBT program for younger children with ASD and comorbid anxiety to the
characteristics and clinical needs of early adolescents. Thereafter, protocol and measure
development will be refined during Phases I and II of this study through our experiences
treating a total of 20 young adolescents (ages 11-14 years - 10 will be treated at USF; 10
at University of California, Los Angeles (UCLA)) with ASD and comorbid anxiety disorder(s).
The CBT protocol will then be examined in a trial comparing CBT to a waitlist condition (N =
32 total; 16 at each study site).

The two recruitment sites for this study are the University of California, Los Angeles and
the University of South Florida. The University of Miami will assist with quality assurance
checks. Considering the rising number of youth diagnosed with ASD, and the lack of tested
treatment options for those young adolescents with comorbid anxiety, our proposed work
toward an efficacious CBT protocol will provide a timely contribution to public health
efforts.