Conversion to Embeda With Rescue Trial

The decision to terminate the trial was based on a lack of study drug supply. The decision
was not based on any safety concerns. The termination letter was sent on 11March2011.

Inclusion Criteria:

- Be able to read, speak and understand English

- Have chronic moderate to severe pain for at least 3 months

- Require around the clock opioid medication for the relief of pain

- Have been taking a daily opioid for at least 30 days prior to starting the study

- Be able to be safely switched to a different pain medication

- Be practicing acceptable birth control methods for female patients of childbearing
potential

- Be willing to participate in the study and able to comply with study procedures

Exclusion Criteria:

- Be currently diagnosed with or participating in and/or seeking treatment for opioid
and/or alcohol abuse

- Be allergic or intolerant to morphine, morphine salts, naltrexone or other opioids

- Be currently taking tramadol and/or extended release morphine products

- Have respiratory depression

- Have acute or severe bronchial asthma or severe chronic obstructive pulmonary disease

- Have migraines as your main source of pain

- Have any form of bowel obstruction

- Be pregnant or breast feeding

- Have had 2 or more surgeries for low back pain

- Be planning a major surgery during the study

- Be staying in a hospital or nursing home

- Be planning to have steroid injections for your chronic pain during the study

- Have a life expectancy of less than 2 months