Mars Flavonol Exercise and Cognitive Function Study

Inclusion Criteria:

1. Age 50-75

2. English-speaking

3. Ambulatory

4. BMI < 32

5. Post-menopausal (women only), no estrogen replacement therapy

6. VO2max < 36 and 33 ml/kg/min for men age 50-59 and 60-69 respectively; < 29 and 27
ml/kg/min for women age 50-59 and 60-75 respectively.

7. Baecke Physical Activity Sports Score ≤ 2

8. Medical clearance to participate in the study (normal serum electrolyte, BUN,
creatinine levels, normal blood pressure and resting cardiogram)

Exclusion Criteria:

1. Use of psychotropic medications

2. Current psychiatric disorder

3. Any condition for which aerobic training is counter-indicated

4. Habitual consumers of dietary or herbal supplements, including Gingko, flavonoid, and
dietary herbal or plant extracts

5. Lactose Intolerance

6. Individuals who report directly to any of the study investigators

7. Diabetes

Exclusion Criteria (MRI-related)

1. Cardiac Pacemaker

2. Internal Pump

3. Insulin Pump

4. Tattoo eyeliner

5. Wire Sutures

6. Internal Metal Objects

7. Metal Slivers in Eye

8. Prosthesis

9. Hearing Aid Implants

10. Neurostimulator

11. Metal Fragments

12. Brain Aneurysm Clips

13. Vascular Clips

14. Breast Expander

15. Vena Cava Filter

16. Heart Valve

17. Metal Stents

18. Asthma

19. Hay-Fever

20. Sickle Cell Disease

21. Kidney Disease

22. Pregnant