Lung Inflammation and Lung Metastases From Breast Cancer
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Lung Cancer, Cancer, Cancer, Pneumonia |
| Therapuetic Areas: | Oncology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/13/2016 |
| Start Date: | August 2010 |
| End Date: | July 2016 |
Association of Smoking, Lung Inflammation and Lung Metastases From Breast Cancer
The purpose of this study is to find out if there is a link between cigarette smoking,
inflammation and the spread of breast cancer to the lung. We think that women who are
current or former smokers may be at increased risk for breast cancer spreading to the lung
compared to women who have never smoked. Smoking causes inflammation in the lung in some
women. Researchers at Memorial Sloan-Kettering (MSKCC) think that smoking-related lung
inflammation may increase the chance of breast cancer spreading to the lung. In order to
find out whether inflammation plays a role in breast cancer spreading to the lung, we will
measure a urinary marker of lung inflammation. This will allow us to determine if this
marker is more commonly elevated in women with breast cancer that has spread to the lung
compared to those without breast cancer in the lung. We will also collect DNA from blood to
have the opportunity to determine if there are differences in DNA in women with or without
breast cancer that has spread to the other sites including the lung. We will also collect
blood to determine if we can identify risk factors for the spread of breast cancer to the
lungs.
inflammation and the spread of breast cancer to the lung. We think that women who are
current or former smokers may be at increased risk for breast cancer spreading to the lung
compared to women who have never smoked. Smoking causes inflammation in the lung in some
women. Researchers at Memorial Sloan-Kettering (MSKCC) think that smoking-related lung
inflammation may increase the chance of breast cancer spreading to the lung. In order to
find out whether inflammation plays a role in breast cancer spreading to the lung, we will
measure a urinary marker of lung inflammation. This will allow us to determine if this
marker is more commonly elevated in women with breast cancer that has spread to the lung
compared to those without breast cancer in the lung. We will also collect DNA from blood to
have the opportunity to determine if there are differences in DNA in women with or without
breast cancer that has spread to the other sites including the lung. We will also collect
blood to determine if we can identify risk factors for the spread of breast cancer to the
lungs.
Inclusion Criteria:
- Registered patient at MSKCC
- Histologically proven breast cancer. It is not necessary that pathology be reviewed
at MSKCC
- Age ≥18 years Group 1 (A and B)
- Diagnosed with metastatic breast cancer on biopsy or imaging study.
- Patients will be considered to have lung metastases, and will be assigned to group 1A
if any of the following criteria are met, otherwise patients will be assigned to
group 1B "No known Lung Metastases," Biopsy-proven lung metastasis.
- Pleural effusion with cytologic evidence of malignancy.
- Pleural effusion, exudative in character, without alternative explanation and
attributed, in the opinion of the clinician to metastatic disease.
- Symptoms attributable to lung metastases and a radiological pattern interpreted by a
radiologist as suspicious for metastatic disease.
- Any pulmonary nodule on chest radiograph, CT scan, PET-CT or MRI, which is
interpreted by the clinician and radiologist to be metastatic in etiology, whether or
not a biopsy was performed, and regardless of symptoms.
- A radiographic pattern interpreted by a radiologist as consistent with lymphangitic
carcinomatosis.
Group 2 (Controls)
- History of early breast cancer and currently no evidence of disease
Exclusion Criteria:
- Inability to provide written informed consent.
- Inability to complete smoking and NSAID questionnaire.
- Steroid use within the previous 4 weeks.
- Radiotherapy to the breast, chest wall or axilla within the previous 3 months.
- Men with breast cancer.
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