Dietary Interventions in Asthma Treatment: Sprouts Study
| Status: | Suspended |
|---|---|
| Conditions: | Allergy, Asthma, Neurology |
| Therapuetic Areas: | Neurology, Otolaryngology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 49 |
| Updated: | 12/14/2017 |
| Start Date: | November 2010 |
Sulforaphane (SFN) is a naturally occurring isothiocyanate that is a potent inducer of Phase
II enzymes which play a critical role in preventing oxidative stress (via activation of
Nrf2). Broccoli sprouts (BS) contain the richest source of SFN.
The main objectives of this study are to test the effect of broccoli sprouts (BS) on
biomarkers of oxidative stress (OS), inflammation, basophil activation, and clinical outcomes
in mouse allergen-induced asthma by (1) determining if BS improves lung function and airways
symptom responses in mouse-sensitized adults with asthma undergoing environmental mouse
allergen challenge (EMAC), (2) examining the effect of BS on OS, inflammation, and basophil
activation, and (3) examining the effect of BS on changes in OS, inflammation, and basophil
activation after EMAC.
II enzymes which play a critical role in preventing oxidative stress (via activation of
Nrf2). Broccoli sprouts (BS) contain the richest source of SFN.
The main objectives of this study are to test the effect of broccoli sprouts (BS) on
biomarkers of oxidative stress (OS), inflammation, basophil activation, and clinical outcomes
in mouse allergen-induced asthma by (1) determining if BS improves lung function and airways
symptom responses in mouse-sensitized adults with asthma undergoing environmental mouse
allergen challenge (EMAC), (2) examining the effect of BS on OS, inflammation, and basophil
activation, and (3) examining the effect of BS on changes in OS, inflammation, and basophil
activation after EMAC.
Inclusion Criteria:
- Age 18-49 years
- Physician-diagnosed asthma
- No other major pulmonary disease such as cystic fibrosis or COPD
- Mouse sensitization, defined by a positive skin prick test to mouse epithelial extract
or positive mouse-specific IgE
- Non-smoker
Exclusion Criteria:
- Severe or unstable asthma defined as requiring hospitalization in the previous year or
intubation in the previous 2 years, or on high-dose inhaled corticosteroids or chronic
oral corticosteroids
- Baseline FEV1 and FEV1/FVC < 70% predicted
- Positive SPT to a pet currently living in the participant's home
- Other significant medical issues such as heart disease or poorly controlled
hypertension, or hypothyroidism
- Pregnancy or nursing/breastfeeding mothers
- On beta-blocker therapy
- Taking anti-oxidant supplements
- Unable to stop antihistamines prior to skin testing
- Unable to stop medications that may interfere with allergen challenge responses prior
to challenges.
- The participant has food allergy to BS or AS.
- Omalizumab use within the last 12 months.
- Oral corticosteroid use within the last 2 weeks.
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