Metabolically Normal and Metabolically Abnormal Obesity
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/13/2015 |
| Start Date: | August 2010 |
| End Date: | August 2015 |
| Contact: | Emily Jenkerson, B.A. |
| Email: | jenkersone@msnotes.wustl.edu |
| Phone: | 314-362-1000 |
The purpose of this study is to learn more about why some obese persons are resistant to
developing obesity-related metabolic diseases (such as diabetes and cardiovascular disease),
while others are prone to developing these conditions. We will do this by studying obese
persons before and after a 5% body weight gain.
Subjects will be asked to increase their current diet for a period of 8-12 weeks in order to
increase their current body weight by 5%. Each will then be asked to maintain this weight
increase for 3 weeks. We will monitor subjects throughout this time period with weekly
medical evaluations. At the completion of the study, we will provide each subject with a
6-month weight loss program.
developing obesity-related metabolic diseases (such as diabetes and cardiovascular disease),
while others are prone to developing these conditions. We will do this by studying obese
persons before and after a 5% body weight gain.
Subjects will be asked to increase their current diet for a period of 8-12 weeks in order to
increase their current body weight by 5%. Each will then be asked to maintain this weight
increase for 3 weeks. We will monitor subjects throughout this time period with weekly
medical evaluations. At the completion of the study, we will provide each subject with a
6-month weight loss program.
Inclusion Criteria:
- Obese subjects (BMI 30.0 - 39.9 kg/m2)
- Sedentary subjects (exercise less than 1 hr/wk)
Exclusion Criteria:
- Pregnant or lactating women
- Michigan Alcohol Screening Test score ≥4
- Active or previous history of liver disease
- Active or previous history of diabetes
- history of alcohol abuse, or currently consuming ≥20 g alcohol/day
- Severe hypertriglyceridemia (>300 mg/dL)
- Smoke tobacco
- Take medication that might confound the study results
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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