Fludrocortisone for Sudden Hearing Loss
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 89 |
| Updated: | 4/2/2016 |
| Start Date: | August 2012 |
| End Date: | August 2016 |
| Contact: | Anh Nguyen-Huynh, MD PhD |
| Email: | nguyanh@ohsu.edu |
| Phone: | 503-494-8135 |
Mineralocorticoid Treatment for Sudden Sensorineural Hearing Loss
The standard of care treatment of sudden hearing loss uses a type of steroid called
glucocorticoid. Examples of glucocorticoids are prednisone, methylprednisolone and
dexamethasone. Not everybody recovers hearing with glucocorticoid treatment. Fludrocortisone
is a different type of steroid called mineralocorticoid. Unlike glucocorticoids, which work
by reducing inflammation, mineralocorticoids work by changing salt and fluid balance. In
animal studies, fludrocortisone is at least as effective as glucocorticoid in preserving
hearing. Fludrocortisone is not approved for the treatment of sudden hearing loss. The
purpose of this study is to test whether fludrocortisone can treat sudden hearing loss.
glucocorticoid. Examples of glucocorticoids are prednisone, methylprednisolone and
dexamethasone. Not everybody recovers hearing with glucocorticoid treatment. Fludrocortisone
is a different type of steroid called mineralocorticoid. Unlike glucocorticoids, which work
by reducing inflammation, mineralocorticoids work by changing salt and fluid balance. In
animal studies, fludrocortisone is at least as effective as glucocorticoid in preserving
hearing. Fludrocortisone is not approved for the treatment of sudden hearing loss. The
purpose of this study is to test whether fludrocortisone can treat sudden hearing loss.
Inclusion Criteria:
- Age 18 or older
- Idiopathic sudden sensorineural hearing loss within 3 months
- Failure to recover hearing with glucocorticoid treatment or inability to tolerate
glucocorticoid
Exclusion Criteria:
- Other diagnosis for the sudden hearing loss
- Concurrent systemic use of another steroid
- Hypersensitivity to fludrocortisone
- Systemic fungal infection
- Hypertension requiring two or more medications
- Pitting edema
- Cardiomegaly
- Congestive heart failure
- Electrolyte abnormality
- Concurrent use of barbiturates, phenytoin, fosphenytoin, rifampin, or rifapentine
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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