The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Diabetes |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 40 - 84 |
| Updated: | 11/22/2018 |
| Start Date: | October 2010 |
| End Date: | December 2013 |
The overall research plan is to test the hypothesis that intraoperative treatment of
hyperinsulinemic normoglycemic clamp (HNC) in cardiac surgical patients improves myocardial
function and short-term outcomes compared with standard glucose management.
hyperinsulinemic normoglycemic clamp (HNC) in cardiac surgical patients improves myocardial
function and short-term outcomes compared with standard glucose management.
Specific Aim #1:To determine whether intraoperative use of HNC affords cardioprotective
benefits measured by improved echocardiographic measures of myocardial function, serum
markers of cardiomyocyte injury, and hemodynamic indices measured immediately (at end of
surgery) and during the short-term (initial hospitalization).
benefits measured by improved echocardiographic measures of myocardial function, serum
markers of cardiomyocyte injury, and hemodynamic indices measured immediately (at end of
surgery) and during the short-term (initial hospitalization).
Inclusion Criteria:
- Age 40 - 84 years old, Aortic stenosis, Scheduled for Aortic valve replacement.
Exclusion Criteria:
- Poor quality echocardiographic images unsuitable for analysis
- Off -pump surgical procedure
- Anticipated deep hypothermic circulatory arrest
- Any contraindications to transesophageal echocardiogram (TEE) or other proposed
intervention
- Unable to give written informed consent (non-English speaking, vulnerable patients,
etc.)
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