Characterization of Rectal Cancer Hypoxia Using pO2 Histography and Immunohistochemistry for Hypoxia-Related Proteins
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 9/23/2012 |
| Start Date: | August 2010 |
| End Date: | August 2013 |
| Contact: | José Guillem, MD |
| Phone: | 212-639-8278 |
The purpose of this study is to see if the cells in rectal cancer are oxygen-starved, or
hypoxic. We know that as cancers grow bigger, parts of them are cut off from the oxygen
supply and they become hypoxic, basically, lacking oxygen. Research has shown that cells
that are oxygen-starved respond differently to treatment such as chemotherapy and radiation
when compared to cells that are oxygen rich.
Inclusion Criteria:
- Biopsy proven adenocarcinoma of the rectum. If a biopsy was taken at an outside
hospital, the slides and diagnosis will be reviewed and confirmed by a pathologist at
MSKCC.
- Mid to distal rectal tumors not requiring pre-op radiation or chemotherapy
- Age ≥ 18
- Age < 90
- Karnofsky performance status ≥ 60
- Ability to understand and the willingness to sign a written informed consent
document.
Exclusion Criteria:
- Current pregnancy
- Uncontrolled intercurrent illness that would limit compliance with study
requirements.
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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