Investigational Study of Oral Fish Oil in Treating Parenteral Nutrition Associated Liver Disease
| Status: | Completed |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | Any - 21 |
| Updated: | 4/2/2016 |
| Start Date: | January 2011 |
| End Date: | January 2012 |
| Contact: | Tom Jaksic, MD, PhD |
| Email: | tom.jaksic@childrens.harvard.edu |
| Phone: | 617 355 9600 |
An Initial Trial of Enteral Fish Oil Supplementation in the Treatment of Parenteral Nutrition-associated Liver Disease in Patients With Short Bowel Syndrome
The purpose of this study is to investigate the usefulness of oral fish oil(Lovaza)in
normalizing liver function in patients who have parenteral nutrition associated liver
disease. The investigators believe that patients who take oral fish oil will normalize liver
function faster than those who do not
normalizing liver function in patients who have parenteral nutrition associated liver
disease. The investigators believe that patients who take oral fish oil will normalize liver
function faster than those who do not
Inclusion Criteria:
- History of parenteral nutrition(PN)administration >4weeks
- PN associated liver disease from intestinal failure
- ability to take full enteral feed
- body weight equal or greater than 3kg
- elevated ALT level twice of that normal(ALT>84)at the time PN is weaned off
Exclusion Criteria:
- Hemodynamic instability
- renal failure
- suspected congenital obstruction of the hepatobiliary system
- diagnosis hepatitis A, B, or C
- diagnosis of alpha 1-antitrypsin deficiency
- diagnosis of cytomegalovirus infection
- diagnosis of HIV
- children in care
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