Study Evaluating The Safety Of AAB-003 (PF-05236812) In Subjects With Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 89
Updated:3/30/2013
Start Date:September 2010
End Date:October 2013
Contact:Pfizer CT.gov Call Center
Phone:1-800-718-1021

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A Phase 1, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Adaptive, Multiple Ascending Dose Study Of The Safety, Tolerability And Pharmacokinetics Of AAB-003 (PF-05236812) In Subjects With Mild To Moderate Alzheimer's Disease


This is a study to evaluate the safety of multiple doses of AAB-003 (PF-05236812) in
patients with mild to moderate Alzheimer's Disease. Patients will receive either AAB-003
(PF-05236812) or placebo. Each patient's participation will last approximately 41 weeks.


Inclusion Criteria:

- Diagnosis of probable Alzheimer's Disease with MMSE score of 16-26, and brain MRI
consistent with the diagnosis of Alzheimer's Disease

- Concurrent use of cholinesterase inhibitor or memantine allowed, if stable.

- Caregiver will participate and be able to attend clinic visits with patient

Exclusion Criteria:

- Significant neurological disease other than Alzheimer's Disease

- Major psychiatric disorder

- Contraindication to undergo brain MRI (e.g., pacemaker, CSF shunt, or foreign metal
objects in the body)

- Women of childbearing potential
We found this trial at
9
sites
Cape Girardeau, Missouri 63703
397
mi
from 43215
Cape Girardeau, MO
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235 East 42nd Street
Clifton, New Jersey 07013
479
mi
from 43215
Clifton, NJ
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Atlanta, Georgia 30309
432
mi
from 43215
Atlanta, GA
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Atlantis, Florida 33462
940
mi
from 43215
Atlantis, FL
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Baltimore, Maryland 21234
346
mi
from 43215
Baltimore, MD
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Biloxi, Mississippi 39531
740
mi
from 43215
Biloxi, MS
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Detroit, Michigan 48202
166
mi
from 43215
Detroit, MI
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Los Angeles, California 90027
1982
mi
from 43215
Los Angeles, CA
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Pittsburgh, Pennsylvania 15212
162
mi
from 43215
Pittsburgh, PA
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