Impact of Parental Support on Pregnancy Outcomes (IPSO) Trial- Day 3 Preimplantation Genetic Screening (PGS) With Day 5 Fresh Transfer

Gene Security Network is recruiting patients for a research study evaluating pregnancy and
implantation rates in women undergoing In Vitro Fertilization (IVF) and Preimplantation
Genetic Screening (PGS). PGS is also referred to as Preimplantation Genetic Diagnosis (PGD)
for aneuploidy.

Healthy women undergoing IVF who are between the ages of 35 to 42 years are being recruited
to participate in a randomized study.

The purpose of this study is to determine whether PGS- testing of embryos created during IVF
for chromosomal abnormalities, prior to transfer to the uterus- improves pregnancy and
implantation rates in patients when compared to patients whose embryos are not tested. PGS
will be conducted using 24 Chromosome Aneuploidy Screening with Parental Support from Gene
Security Network.

All subjects who qualify and enroll will receive discounted IVF medications (both TEST and
CONTROL arms). If you become pregnant during the study, you will receive a small payment for
providing information about your pregnancy and birth. If you are assigned to the TEST arm of
the study you will receive free PGS.