Imaging of Traumatic Brain Injury
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/27/2018 |
| Start Date: | March 21, 2010 |
| End Date: | September 5, 2015 |
Prognostic Value of MR Imaging Markers in the Assessment of Traumatic Brain Injury Patients
This project aims to study the prognostic ability of various MRI imaging markers in the
evaluation of TBI patients. Cognitive, social, and occupational recovery will be measured at
each time point, and compared to MRI findings. Healthy volunteers will serve as a comparison
to the TBI patients.
It is hypothesized that novel MRI markers of metabolism, hemodynamics, functional
connectivity, and tissue microstructure will be related to the clinical status of the
patient, as well as their social and occupational outcomes.
evaluation of TBI patients. Cognitive, social, and occupational recovery will be measured at
each time point, and compared to MRI findings. Healthy volunteers will serve as a comparison
to the TBI patients.
It is hypothesized that novel MRI markers of metabolism, hemodynamics, functional
connectivity, and tissue microstructure will be related to the clinical status of the
patient, as well as their social and occupational outcomes.
The goal of this study is to identify advanced magnetic resonance imaging markers that can
serve as a prognostic marker in the evaluation and management of traumatic brain injury
patients.
Magnetic resonance imaging and cognitive testing (when possible) will be performed in the
acute (within 10 days following injury), and recovery stages (about 1 month, about 6
months,and about 18 months). The relationship between the advanced magnetic resonance imaging
markers and the clinical condition of the patient will be evaluated at each time point to
determine which combination of imaging markers best describe the current clinical status of
the patient and which markers best predict a patient's outcome status.
serve as a prognostic marker in the evaluation and management of traumatic brain injury
patients.
Magnetic resonance imaging and cognitive testing (when possible) will be performed in the
acute (within 10 days following injury), and recovery stages (about 1 month, about 6
months,and about 18 months). The relationship between the advanced magnetic resonance imaging
markers and the clinical condition of the patient will be evaluated at each time point to
determine which combination of imaging markers best describe the current clinical status of
the patient and which markers best predict a patient's outcome status.
Inclusion Criteria:
- Age 18 or older
- Evidence of external head injury or facial trauma, or mechanism of injury consistent
with brain trauma, including loss of consciousness or altered mental status.
- Residence within 90 minutes driving time of University of Maryland Medical Center, and
willingness to attend follow-up appointments.
Exclusion Criteria:
- History of white matter disease or neurodegenerative disorders including Multiple
Sclerosis, Huntington's Disease, Alzheimer's Disease, or Pick's Disease.
- History of Stroke
- History of treatment or diagnosis of psychiatric conditions: Major Depressive Disorder
(MDD), Bipolar Disorder (BPD), Schizophrenia, or Dementia of any type.
- History of Brain Tumor
- Status post trauma due to asphyxiation
- Preexisting contraindications for Magnetic Resonance Imaging (MRI)
- Active Duty Military Status
- Police custody or prisoner status
- Pregnant women
We found this trial at
1
site
University of Maryland Medical Center Founded in 1823 as the Baltimore Infirmary, the University of...
Click here to add this to my saved trials
