Endovenous Ablation With and Without Polidocanol Endovenous Microfoam Treatment for Patients With Great Saphenous Vein Incompetence and Visible Varicosities

Varicose veins are enlarged, noticeably bulging veins, which commonly occur in the legs and
may cause discomfort. In this study, patients with varicose veins in the legs will be
participating. The purpose of this research study is to evaluate the safety and
effectiveness of two different doses of an investigational drug, Polidocanol Endovenous
Microfoam (PEM) compared to vehicle (inactive solution) when used following an approved heat
treatment in subjects with varicose veins.