Effects of Dronedarone on Cardiac Geometry and Function in Patients With Atrial Fibrillation and Left Atrial Enlargement
| Status: | Archived |
|---|---|
| Conditions: | Atrial Fibrillation, Orthopedic |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | September 2010 |
| End Date: | June 2012 |
A Placebo-Controlled, Double-Blind, Randomized, Multi-center Study to Assess the Effects of Dronedarone 400 mg BID on Cardiac Geometry and Function in Patients With Atrial Fibrillation and Left Atrial Enlargement
Primary Objective:
- Evaluate the effect of dronedarone versus placebo (standard therapy) in slowing the
progression of adverse left atrial remodeling in patients with atrial fibrillation (AF)
following 12 months of treatment
Secondary Objectives:
- Evaluate the effects of dronedarone versus placebo on left atrial function
- Evaluate the effects of dronedarone versus placebo on left atrial dimension
- Evaluate the effects of dronedarone versus placebo on left ventricular function (LVEF,
E, E', A, E/E')
- Evaluate the safety and tolerability of dronedarone
The total study period per subject is 12.5 months broken down as follows:
- Treatment period: 12 months
- Follow-up period: 2 weeks
We found this trial at
30
sites
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University of Chicago One of the world's premier academic and research institutions, the University of...
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Virginia Commonwealth University Medical Center The Virginia Commonwealth University Health System is an urban, comprehensive...
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