The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 11/30/2013 |
| Start Date: | October 2010 |
| End Date: | October 2012 |
| Contact: | Gretchen A Upton |
| Email: | uptong@ccf.org |
| Phone: | 216-444-3289 |
To evaluate the effects of dexmedetomidine and propofol on cerebral blood flow and brain
oxygenation during Deep Brain Stimulation (DBS) surgery. Specifically, the investigators
will test the hypothesis that dexmedetomidine is non-inferior to propofol for cerebral blood
flow as measured by transcranial Doppler and brain oxygenation as measured by near-infrared
spectroscopy.
Inclusion Criteria:
- ASA I-III.
- Scheduled for DBS.
Exclusion Criteria:
- History of dystonia.
- Severe heart failure with ejection fraction less than 30%.
- History of obstructive sleep apnea.
- History of renal failure with creatinine level > 2 mg/dl.
- Allergies to α-2 agonists and propofol.
- Current use of α-2 agonist medications such as clonidine.
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