Study of Recently HIV Infected Men and Transmission Behaviors
| Status: | Completed |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | February 2009 |
| End Date: | August 2013 |
| Contact: | Leonardo Colemon, MA |
| Email: | leocolemon@ucla.edu |
| Phone: | 3108256094 |
Transmission Behavior in Partnerships of Newly HIV Infected Southern Californians
Specific Aim 1: Identify drug use patterns and partnership dynamics that mediate risk
behaviors over time in a cohort of recently HIV infected men and their partners.
Specific Aim 2: Determine predictors of transmission risk within partnerships of recently
HIV infected men and their partners, using the partnership as the unit of analysis.
Specific Aim 3: Quantify the long-term population-level impacts of voluntary behavior change
by men with recent HIV infection, through the use of dynamic mathematical modeling that
integrates our data on behavior change with current estimates of temporal infectiousness
patterns. The investigators will also determine whether more frequent testing and/or
development of tests with earlier sensitivity may have a significant impact on the epidemic.
Finally, the magnitude of this effect to that obtained by decreasing drug use or risky
sexual behavior prior to or following seroconversion will be compared. This will be
conducted as a statistical analysis by co-investigators at the University of Washington.
behaviors over time in a cohort of recently HIV infected men and their partners.
Specific Aim 2: Determine predictors of transmission risk within partnerships of recently
HIV infected men and their partners, using the partnership as the unit of analysis.
Specific Aim 3: Quantify the long-term population-level impacts of voluntary behavior change
by men with recent HIV infection, through the use of dynamic mathematical modeling that
integrates our data on behavior change with current estimates of temporal infectiousness
patterns. The investigators will also determine whether more frequent testing and/or
development of tests with earlier sensitivity may have a significant impact on the epidemic.
Finally, the magnitude of this effect to that obtained by decreasing drug use or risky
sexual behavior prior to or following seroconversion will be compared. This will be
conducted as a statistical analysis by co-investigators at the University of Washington.
People who recently became infected with HIV often have a high level of the virus and may be
highly infectious. If they have sex (especially anal intercourse) without condoms soon after
they have been infected with HIV, there is a great chance that they may transmit the virus
to others. When they learn of their HIV infection, some but not all men change sexual
behaviors so as not to infect their partner(s) with HIV. Possible reasons for such behavior
change include increase or decrease in drug use and what is going on within their sexual
partnerships. A study that tracks men with recent HIV infection and their partners over time
can provide information key to stopping further spread of HIV given that sexual behaviors
can vary over time, especially during this most infectious period.
This study will look at how likely it is for HIV infection to be spread among partner types
over time by recently HIV-infected men and their partners. The study will compare behaviors
of recently HIV infected men to those with long-term HIV infection and no HIV infection. It
will allow a study of sexual partnerships by actively recruiting sexual partners. We will
also focus on the role of drug use, especially methamphetamine and how it changes behaviors
over time. We will especially look at how different sex partners affects one's drug use and
increases or decreases HIV transmission. The study will enroll 150 recently HIV-infected men
who have sex with men and follow them for a year. In addition, up to 6 sexual partners of
each recently HIV infected individual will be recruited and followed for a year. Some sexual
partners will be HIV negative and some HIV positive. We will use their HIV status to compare
behaviors over time in the group and between partners of the same status and partners of a
different status. The results will be used in special formulas that will allow for a better
understanding of behavior change by men with recent HIV infection. This new information will
be key for designing new ways to target risk reduction for recently HIV-infected men.
highly infectious. If they have sex (especially anal intercourse) without condoms soon after
they have been infected with HIV, there is a great chance that they may transmit the virus
to others. When they learn of their HIV infection, some but not all men change sexual
behaviors so as not to infect their partner(s) with HIV. Possible reasons for such behavior
change include increase or decrease in drug use and what is going on within their sexual
partnerships. A study that tracks men with recent HIV infection and their partners over time
can provide information key to stopping further spread of HIV given that sexual behaviors
can vary over time, especially during this most infectious period.
This study will look at how likely it is for HIV infection to be spread among partner types
over time by recently HIV-infected men and their partners. The study will compare behaviors
of recently HIV infected men to those with long-term HIV infection and no HIV infection. It
will allow a study of sexual partnerships by actively recruiting sexual partners. We will
also focus on the role of drug use, especially methamphetamine and how it changes behaviors
over time. We will especially look at how different sex partners affects one's drug use and
increases or decreases HIV transmission. The study will enroll 150 recently HIV-infected men
who have sex with men and follow them for a year. In addition, up to 6 sexual partners of
each recently HIV infected individual will be recruited and followed for a year. Some sexual
partners will be HIV negative and some HIV positive. We will use their HIV status to compare
behaviors over time in the group and between partners of the same status and partners of a
different status. The results will be used in special formulas that will allow for a better
understanding of behavior change by men with recent HIV infection. This new information will
be key for designing new ways to target risk reduction for recently HIV-infected men.
Inclusion Criteria:
18 years of age or older Male Documented HIV infection that occurred within previous 12
months Willing to complete study procedures Mentally competent to give informed consent
Willingness to refer partners to study Ability to complete practice questions for the
web-based system
Exclusion Criteria:
Less than 18 years of age No report of sex with another man in the past 12 months
Unwilling to be tested for HIV including:
Unwilling to complete study follow-up questionnaires Not mentally competent to understand
study procedures and give informed consent Unwilling to provide an email address or create
one for the study
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