A Rheumatoid Arthritis Study in Participants

In consideration of disease severity, all participants were assessed for non-response at Week
16. A total of 66 joints were examined for swelling, and a total of 66 joint were examined
for tenderness. For participants who had at least 5 swollen and 5 tender joints at baseline,
Week 16 non-responders (NRs) were defined as participants with <20% improvement from baseline
in both tender joint counts and swollen joint counts. For participants who did not have at
least 5 swollen and 5 tender joints at baseline, Week 16 NRs were defined as participants who
had at least 2 additional tender and 2 additional swollen joints from baseline. All Week 16
NRs and all participants who discontinued study treatment at any time, for any reason, were
defined as NRs starting at that timepoint and going forward for all American College of
Rheumatology (ACR) imputed analyses, including the Week 24 endpoint.

Inclusion Criteria:

- Diagnosis of Rheumatoid Arthritis (RA) of more than 6 months and less than 15 years

- Global Assessment of Disease Activity visual analog scale (VAS) greater than or equal
to 20/100 millimeters (mm)

- If on one or more conventional disease-modifying anti-rheumatic Drugs (DMARDs) at
randomization, must have been on a stable dose for at least 8 weeks prior to study
start.

- Women must not be pregnant, breastfeeding, or become pregnant during the study

Exclusion Criteria:

- Use of unstable doses of non-steroidal inflammatory drugs (NSAIDS) in the past 6 weeks

- Steroid injection or intravenous (IV) infusion in the last 6 weeks

- Use of more than 10 milligrams per day (mg/day) of oral steroids in the last 6 weeks

- Use of biologic DMARD concurrently or recently

- History of a serious reaction to other biological DMARDs

- Use of an oral calcineurin inhibitor (for example, cyclosporin or tacrolimus) in the
last 8 weeks

- Surgery on a joint or other major surgery less than 2 months prior to study start, or
plans to have joint surgery or major surgery during the study

- Active fibromyalgia, juvenile chronic arthritis, spondyloarthropathy, Crohn's disease,
ulcerative colitis, psoriatic arthritis, or other systemic inflammatory condition
except RA

- Cervical cancer or squamous skin cancer within the past 3 years, or other cancer
within the past 5 years

- Received a live vaccine within the past 12 weeks (for example, vaccines for measles,
mumps, rubella, and chicken pox, and nasal-spray flu vaccines)

- Hepatitis or human immunodeficiency virus (HIV)

- A serious bacterial infection (for example, pneumonia or cellulitis) within 3 months
or a serious bone or joint infection within 6 months

- Symptoms of herpes zoster or herpes simplex within the last month

- Active or latent tuberculosis (TB)

- Current symptoms of a serious disorder or illness

- Use of an investigational drug within the last month