Correlation of High Resolution Esophageal Manometry With Symptoms
| Status: | Archived |
|---|---|
| Conditions: | Angina, Gastroesophageal Reflux Disease , Gastrointestinal |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Gastroenterology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | February 2010 |
| End Date: | March 2013 |
High Resolution Manometry is a new technology that utilizes 36 solid state sensors on a thin
catheter spaced at 1-cm intervals. One can more effectively measure the pressure of the
esophagus. It includes a sophisticated software to display the pressures data as color
topography plot using time, length of the esophagus and pressure within the entire
esophagus. It is unclear if this technology improvement actually correlates with patient's
symptoms.
In a 2007 retrospective study performed using this technology, 400 subjects referred to the
motility lab underwent high resolution manometry (HRM) for complaints of dysphasia,
gastroesophageal reflux disease, chest pain and miscellaneous complaints. HRM offered
greater detail of individual contracting segments of the esophagus, including the duration
of contraction and propagation of individual contractions.
For example, a new subclass of achalasia was defined by HRM. In this classification,
achalasia is divided into types 1, 2 and 3. Type 1 corresponds to classic achalasia
(complete esophageal motor failure), type 2 is a compression achalasia (simultaneous
panesophageal pressurization with aperistalsis), and type 3 is spastic achalasia with
aperistalsis (100% spasm). However, it is unclear if this categorization represents a
spectrum of disease among patients with achalasia, or it represents distinct subgroups of
patients with different symptom presentation and etiology.
This study will attempt to correlate the data from HRM to patient's chief compliants,
symptom severity, and clinical presentation.
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