Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers



Status:Completed
Conditions:Healthy Studies
Therapuetic Areas:Other
Healthy:No
Age Range:18 - Any
Updated:11/19/2017
Start Date:November 15, 2010
End Date:May 17, 2011

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Trial Summary
Trial Overview
Inclusion Criteria

Absorption of "ABH Gel" (Ativan®, Lorazepam; Benadryl®, Diphenhydramine; and Haldol®, Haloperidol Gel) From the Skin of Normal Volunteers

RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into
the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial
studies lorazepam, diphenhydramine hydrochloride, and haloperidol gel in healthy volunteers.

OBJECTIVES:I. To study the absorption of the three components in the topical ABH gel in 10
healthy volunteers, and determine if there are any adverse effects. OUTLINE: Patients apply
lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes. After
completion of study treatment, patients are followed up for 5 hours.

Inclusion Criteria:

- Completed a medical screening questionnaire

- English speaking

- No allergies to the drugs

- Able to complete the forms

- If a woman of childbearing age, agree to use contraception

Exclusion Criteria:

- History of substance abuse, psychiatric disorder, acquired brain injury, the
possibility of pregnancy (not using birth control, and of child bearing age)

- Use of any medication that would contraindicate benzodiazepine administration

- Pregnant or nursing
We found this trial at
1
site
Virginia Commonwealth University Massey Cancer Center
401 College Street
Richmond, Virginia 23298
(804) 828-0450
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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mi
from
Richmond, VA
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