Study Evaluating The Safety And Efficacy Of PF-03049423 In Subjects With Ischemic Stroke

The interim analysis for the POC study A9541004 demonstrated futility, and the study was
stopped on the 6th of November 2013. There were no signals of serious safety concern.

Inclusion Criteria:

- Diagnosis of ischemic stroke with an onset within 72 hours prior to start of study
agent administration, male or female.

- Supratentorial ischemic stroke involving the cortex documented by neurological exam
and confirmed by MRI.

- Stroke involving upper extremity.

- Subjects who received thrombolytic therapy may be enrolled and the use of
antiplatelet is acceptable.

Exclusion Criteria:

- Any other severe acute or chronic medical or psychiatric condition besides the
stroke.

- Women of child bearing potential.

- Uncontrolled hypertension.