Longitudinal Study of Dental Implant Therapy in HIV- Positive Patients

The purpose is to place implants and restore them with crowns in both HIV positive and HIV
negative patients then follow patients 3 years period of time, to evaluate how well dental
implants perform in HIV-positive patients versus HIV-negative patients.

Inclusion Criteria:

1. The existence of one or more non-adjacent teeth in the aesthetic zone that are
scheduled for extraction

2. Healthy enough to undergo the proposed therapy without compromise to existing health
status

3. At least 19 years old

4. Able to read and understand written English without the aid of ad hoc interpretation

5. Able to cognitively understand the proposed study and therapy and possible prognoses

6. Able to consent for their own inclusion in the study.

Hemoglobin >8g/dl Absolute neutrophil count >750/mm3 Platelet count>75,000cells/mm3 AST< 5
times the upper limit of normal (ULN) Bilirubin< 2.5 times ULN Alkaline phosphate < 5 times
ULN Creatinine< 2.5 mg/ml Non- smoker (quite smoking at least 6 months) Controlled Type II
diabetes Controlled hypertension Non bisphosphate user Non- bruxer Misch Available Bone
classification divisions A, B, C Misch Bone Density classification D1, D2, D3 Minimal
available bone width 5mm Minimal available bone height 10mm Minimum bone graft with freeze
dried demineralised bone upon implant placement Extraction site has to be healed up for
minimum 6 months before implant placement

Implant supported restorations are limited to the following edentulous areas:

Mandibular arches, excluding 3rd molar areas Maxillary anterior and premolar areas

Exclusion Criteria:

1. Women who are pregnant or lactating at the time of enrollment

2. Previous malignant neoplasm

3. A known hypersensitivity to Titanium metal

4. Any medication/condition that in the opinion of the clinical investigators may
adversely affect bone healing

5. Any indication of an inability to autonomous decisions