Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls
| Status: | Archived |
|---|---|
| Conditions: | Schizophrenia, Smoking Cessation, Tobacco Consumers |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | June 2009 |
| End Date: | June 2011 |
This project tests two hypotheses concerning the low smoking cessation rates in smokers with
schizophrenia. The first hypothesis is that smokers with schizophrenia experience stronger
and more sustained effects of smoking abstinence on negative mood and smoking urge than
control smokers without psychiatric illness. The second hypothesis is that smokers with
schizophrenia experience stronger reinforcing effects of a smoking lapse (i.e., more
rewarding effects of smoking after a period of abstinence) than control smokers without
psychiatric illness.
In this study, smokers with schizophrenia and smokers without psychiatric illness
participate in a nicotine preference task before and after a 3-day period of continuous
smoking abstinence. The investigators will experimentally control abstinence by providing
participants with high-value cash incentives contingent upon smoking abstinence verified
with breath carbon monoxide levels. The investigators will measure nicotine withdrawal and
smoking urge during the abstinence period. In the nicotine preference task, participants
will make choices between nicotine-containing and denicotinized cigarette puffs to provide a
measure of nicotine reinforcement, and the investigators will also measure the effects of
smoking on mood. After the second nicotine preference task, participants will receive a
small-value reinforcer if they continue to abstain for another day, and the investigators
will measure time to the second lapse.
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