Study of the Inhibition of [11C]R-rolipram Binding to Brain Phosphodiesterase - 4 (PDE-4) by HT-0712
| Status: | Archived |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | September 2010 |
| End Date: | March 2011 |
A PET Study: Single-dose, Open-label Study of the Inhibition of [11C]R-rolipram Binding to Brain Phosphodiesterase - 4 (PDE-4) by HT-0712
This Positron Emission Tomography (PET) imaging study is designed to explore the
relationship between HT-0712 dose level and inhibition of brain phosphodiesterase-4
activity, in order to optimize the dosage regimens utilized in subsequent trials.
The objective of this project is to demonstrate the inhibition of human brain PDE4 by
HT-0712, by measuring the inhibition of [11C]R-rolipram binding, a radiotracer which also
binds to and inhibits PDE4. Plasma samples will be drawn to determine if there is a
relationship between plasma pharmacokinetics of HT-0712 and its pharmacodynamic effect, as
determined through the inhibition of [11C]R-rolipram binding in the brain.
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