Cranberry Proanthocyanidins for Modification of Intestinal E. Coli Flora and Prevention of Urinary Tract Infections in UTI-Susceptible Women
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease, Urology, Urinary Tract Infections |
| Therapuetic Areas: | Immunology / Infectious Diseases, Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | September 2010 |
| End Date: | September 2012 |
The purpose of the research is to determine if eating sweetened, dried cranberries or
strawberry fruit pieces will increase the types of different E. coli bacteria in the
intestines which may reduce the likelihood of a major, or highly harmful urinary type of
bacteria which cause urinary tract infections in susceptible women.
strawberry fruit pieces will increase the types of different E. coli bacteria in the
intestines which may reduce the likelihood of a major, or highly harmful urinary type of
bacteria which cause urinary tract infections in susceptible women.
This is a research study about the number and types of bacteria that cause urinary tract
infections (E. coli strains) that are present in the intestine. The bacteria will be
collected and analyzed before and after eating either sweetened, dried cranberries or
strawberry fruit pieces. This study will help us learn more about whether or not the
components of consumed sweetened, dried cranberries or strawberry fruit pieces reduce the
numbers of harmful E. coli bacteria in the vaginal and intestinal tracts, thereby reducing
the number of urinary tract infections among women.
infections (E. coli strains) that are present in the intestine. The bacteria will be
collected and analyzed before and after eating either sweetened, dried cranberries or
strawberry fruit pieces. This study will help us learn more about whether or not the
components of consumed sweetened, dried cranberries or strawberry fruit pieces reduce the
numbers of harmful E. coli bacteria in the vaginal and intestinal tracts, thereby reducing
the number of urinary tract infections among women.
Inclusion Criteria:
- Women, ages 18-65
- History of recurrent urinary tract infections defined as three in the past year, or
two in the last six months
- Subjects must be willing to follow the study protocol that includes consuming the
mandatory daily dose of cranberries or strawberry fruit pieces and traveling to the
UWHC Urology clinic for scheduled rectal and vaginal swab procedures.
The non-UTI-susceptible group will include women ages 18-65 with no history of recurrent
UTI's as defined above.
Exclusion Criteria:
Women who:
- Are pregnant
- Have an immune compromising disease
- Have diabetes
- Have kidney stones
- Have chronic bowel inflammatory disease
- Have known allergies to cranberries, strawberries, elderberries, or wheat fiber
Non-UTI-susceptible group will include women ages 18-65 with no history of recurrent UTI's
as defined above.
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