Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis



Status:Completed
Conditions:Cognitive Studies, Neurology, Multiple Sclerosis
Therapuetic Areas:Neurology, Psychiatry / Psychology, Other
Healthy:No
Age Range:18 - 60
Updated:11/23/2013
Start Date:July 2010
End Date:November 2013
Contact:Barbara S Giesser, MD
Email:bgiesser@mednet.ucla.edu
Phone:310-825-7313

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Trial Summary
Trial Overview
Inclusion Criteria

Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise
has been shown to improve memory and thinking in persons with diseases such as Alzheimer's.
This study will investigate whether a program of aerobic exercise can improve memory and
thinking in persons with MS


Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a
protocol with two intervention arms. One group will have aerobic training on a recumbent
cross trainer three times a week for 20-30 minutes/session. The other group will participate
in stretching exercises at the same frequency and intensity.Total training time will be six
months.Outcome measures will include tests of memory and thinking, and fitness measures.

Inclusion Criteria:

- Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent
cross trainer

Exclusion Criteria:

- Cardiopulmonary or structural disease that would limit ability to participate in
exercise training On treatment with chemotherapy or natalizumab Screening score of
>50 on PASAT
We found this trial at
2
sites
CAl State University at Northridge
Northridge, California 91330
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Northridge, CA
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UCalifornia at Los Angeles
Los Angeles, California 90095
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from
Los Angeles, CA
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