Neoadjuvant Chemotherapy IV Carboplatin With Weekly Paclitaxel \Bevacizumab for Primary Ovarian
| Status: | Completed |
|---|---|
| Conditions: | Ovarian Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 2/10/2018 |
| Start Date: | September 2010 |
| End Date: | May 2015 |
Phase I Evaluation of Intravenous Carboplatin With Weekly Paclitaxel and Bevacizumab in Patients Undergoing Neoadjuvant Chemotherapy for Epithelial Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
The purpose of this study is to determine the maximum tolerated dose (MTD) of intravenous
weekly paclitaxel given with intravenous carboplatin and bevacizumab in patients with
epithelial ovarian, primary peritoneal, or fallopian tube carcinoma that are to receive
neoadjuvant chemotherapy (prior to surgical cytoreduction). Patients will then undergo
surgery which will allow an objective measure of response to the above regimen as well as
assessment of surgical outcomes.
weekly paclitaxel given with intravenous carboplatin and bevacizumab in patients with
epithelial ovarian, primary peritoneal, or fallopian tube carcinoma that are to receive
neoadjuvant chemotherapy (prior to surgical cytoreduction). Patients will then undergo
surgery which will allow an objective measure of response to the above regimen as well as
assessment of surgical outcomes.
Phase I study proposed to evaluate:
- Tolerability of IV regimen carboplatin, paclitaxel and bevacizumab in the neoadjuvant
setting prior to surgery.
- Safety/Toxicity of IV regimen in this patient population
- Treatment is Carboplatin area under the concentration curve (AUC) 5, Bevacizumab
15mg/m2, and starting dose of paclitaxel of 60mg/m2 and will be escalated in intervals
of 10mg/m2 to a maximum dose of 80mg/m2.
- Patients will receive cycles 1-3 of carboplatin, bevacizumab, and paclitaxel and then
cycle 4 will be carboplatin and paclitaxel followed by surgical intervention within 6
weeks of cycle 4.
- Post surgical treatment per physician discretion
- Tolerability of IV regimen carboplatin, paclitaxel and bevacizumab in the neoadjuvant
setting prior to surgery.
- Safety/Toxicity of IV regimen in this patient population
- Treatment is Carboplatin area under the concentration curve (AUC) 5, Bevacizumab
15mg/m2, and starting dose of paclitaxel of 60mg/m2 and will be escalated in intervals
of 10mg/m2 to a maximum dose of 80mg/m2.
- Patients will receive cycles 1-3 of carboplatin, bevacizumab, and paclitaxel and then
cycle 4 will be carboplatin and paclitaxel followed by surgical intervention within 6
weeks of cycle 4.
- Post surgical treatment per physician discretion
Inclusion Criteria:
- histology,cytologically diagnosed epithelial ovarian, primary peritoneal or fallopian
tube cancer
- FIGO (International Federation of Gynecology and Obstetrics stage III or IV disease
- GOG (Gynecologic Oncology Group) Performance Status 0,1,2
- No prior surgery for their malignancy
- Adequate bone marrow function
- Platelet count greater than or equal to 100,000
- Renal Function: Creatinine < 1.5 institutional upper limit normal
- Hepatic Function: Bilirubin less than 1.5 ULN (upper limit of normal)
- Hepatic Function: SGOT (serum glutamate oxaloacetate transaminase) and Alkaline
Phosphate
- Neurologic Function: Neuropathy less than CTCAE (Common Toxicity Criteria for Adverse
Effects)grade 1
- Coagulation Functions: INR<1.5 and PTT ,1.2 times the upper limit of normal
- Measurable disease
Exclusion Criteria:
- Previous cancer related surgery
- Received prior chemotherapy, immunotherapy, radiotherapy, hormonal therapy or biologic
therapy for their ovarian, fallopian tube or primary peritoneal cancer.
- Borderline ovarian tumors, recurrent epithelial ovarian or primary peritoneal cancer
or non-epithelial ovarian are not eligible.
- Other cancers within 5 years (other than non-melanoma skin cancer)
- Acute Hepatitis or end stage liver disease
- History of prior gastrointestinal perforation
- Evidence of abdominal free air not explained by paracentesis
- Sign or symptoms of gastrointestinal obstruction
- Active bleeding or pathologic conditions that carry high risk of bleeding
- CNS (Central Nervous System) disease
- Clinically Significant cardiovascular disease
- Known hypersensitivity to Chinese Hamster ovary cell products or other recombinant
human or humanized antibodies
- Clinically significant proteinuria.
- Hypertensive crises or hypertensive encephalopathy
- History of hemoptysis
- Any non-study related invasive procedure within 28 days fo first date of bevacizumab
- GOG performance status 3 or 4
- Patients who are pregnant or nursing.
- Under the age of 18
- Received prior treatment of bevacizumab or any anti-VEGF (vascular endothelial growth
factor) drug
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