Pancreatic Intraepithelial Neoplasia (PanIN) and the Association With Recurrence of Pancreatic Adenocarcinoma
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer, Cancer, Pancreatic Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 2/10/2018 |
| Start Date: | March 18, 2009 |
| End Date: | July 2020 |
Refining the Molecular Progression From Intraductal to Invasive Pancreatic Cancer: Correlating Genetic Profiles and Clinicopathological Phenotypes in Sporadic and Familial Pancreatic Adenocarcinoma
The research purpose of this project is to create a registry, and blood and tissue bank for
individuals at high-risk for pancreatic cancer. We plan to conduct histopathological and
molecular analysis of resected pancreatic tissue prospectively collected from a cohort of
pancreatic cancer patients.
individuals at high-risk for pancreatic cancer. We plan to conduct histopathological and
molecular analysis of resected pancreatic tissue prospectively collected from a cohort of
pancreatic cancer patients.
Pancreatic cancer is the fifth leading cause of cancer-related death in the United States. In
order to improve outcomes of this disease, significant research efforts have focused on
understanding the changes that occur in the pancreas prior to tumor occurrence. The types of
changes most often associated with tumor have been named pancreatic intraepithelial neoplasia
(PanIN). It is not yet clear how to identify the PanIN lesions most likely to develop into
cancer and the length of time required for this progression. In order to evaluate these
questions, we are interested in examining the microscopic and genetic characteristics of
PanIN lesions in two "high-risk" patients: 1) patients who underwent surgery for pancreatic
cancer and developed tumor recurrence after surgery and 2) patients with a strong family
history of pancreatic cancer or with a genetic syndrome that puts them at risk for pancreas
cancer. The surgical specimens from these patients will be evaluated by a pathologist for
evidence of widespread PanIN lesions. In addition, PanIN lesions will be tested for
abnormalities in several major genes that are known to be important in pancreatic cancer.
order to improve outcomes of this disease, significant research efforts have focused on
understanding the changes that occur in the pancreas prior to tumor occurrence. The types of
changes most often associated with tumor have been named pancreatic intraepithelial neoplasia
(PanIN). It is not yet clear how to identify the PanIN lesions most likely to develop into
cancer and the length of time required for this progression. In order to evaluate these
questions, we are interested in examining the microscopic and genetic characteristics of
PanIN lesions in two "high-risk" patients: 1) patients who underwent surgery for pancreatic
cancer and developed tumor recurrence after surgery and 2) patients with a strong family
history of pancreatic cancer or with a genetic syndrome that puts them at risk for pancreas
cancer. The surgical specimens from these patients will be evaluated by a pathologist for
evidence of widespread PanIN lesions. In addition, PanIN lesions will be tested for
abnormalities in several major genes that are known to be important in pancreatic cancer.
Inclusion Criteria:
- Tissue-confirmed diagnosis of pancreatic adenocarcinoma.
- Underwent surgical resection for adenocarcinoma at Columbia-Presbyterian Medical
Center with pathologically negative surgical margins.
- Enrolled in our Pancreatic Cancer Registry and Tissue Bank protocol (AAAA-6154).
- Have at least 2 relatives (of whom one must be first-degree relative) with pancreatic
cancer, or have been diagnosed with a a genetic syndrome which is associated with
pancreatic cancer (among the included syndromes include BRCA1/2, FAMMM, Peutz-Jeghers,
HNPCC, Hereditary Pancreatitis) —OR— Have radiological or pathological (fine needle
aspirate or surgical biopsy) evidence of local tumor recurrence following surgery.
Exclusion Criteria:
- Metastatic disease discovered at presentation or on recurrence (exception is the
familial PDC patients)
- Positive surgical margins.
- Lack of clinical followup at one year following surgery
We found this trial at
1
site
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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