Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene

Based on the recommendation of the Data Monitoring Committee, OSI-906 and matching placebo
are no longer being administered as of 01 March 2013.

This is a multi-center, randomized (1:1), double-blind, placebo-controlled, phase 2 study.
Patients will be stratified according to the following 2 parameters: (1) EGFR activating
mutation type (exon 19 deletion versus exon 21 single point mutation); and (2) Eastern
Cooperative Oncology Group (ECOG) performance status (0 vs. 1).

Inclusion Criteria:

- Historically confirmed advanced NSCLC stages IIIB or IV

- Exon 19 deletion or exon 21 activating mutation in EGFR

- EGFR mutation status must be confirmed for participation in the study. EGFR can be
performed either by central or local laboratory. If analysis is done locally,
verifiable documentation confirming the EGFR mutation status must be submitted for
review and approval by sponsor prior to randomization. If no local result is
available, formalin-fixed, paraffin-embedded archival tissue representative of the
tumor or, in the absence of archival tissue, a fresh tumor tissue sample of sufficient
size to perform EGFR mutation analysis must be submitted centrally. Results of the
central analysis must be available prior to randomization. Additionally, subjects
should provide tissue blocks for biomarker central analysis whenever possible. Ideal
tissue requirement: block with ≥5 mm2 tumor area sufficient to provide four 4-micron,
and five 10-micron sections

- Measurable disease according to RECIST (version 1.1)

- ECOG performance status 0-1

- Must be able to take oral medication

- Fasting glucose <= 150 mg/dL (8.3 mmol/L). Concurrent use of non-insulinotropic anti
hyperglycemic therapy is permitted if the dose has been stable for >= 4 weeks at the
time of randomization

- Adequate hematopoietic, hepatic, and renal function as follows:

- Neutrophil count >= 1500/uL

- Platelet count >= 100,000/uL

- Serum creatinine <= 1.5 x Upper Limit of Normal (ULN)

- Potassium, magnesium, and calcium within normal limits (supplementation and
re-testing is permitted)

- Total bilirubin <= 1.5 x ULN

- AST and ALT <= 2.5 x ULN, or <= 5 x ULN if patient has documented liver
metastases

- Female subject must be either:

- Of non child bearing potential:

1. post-menopausal (defined as at least 1 year without any menses) prior to
Screening, or

2. documented surgically sterile or status post hysterectomy (at least 1 month
prior to Screening).

- Or, if of childbearing potential:

1. must have a negative urine pregnancy test at Screening, and

2. must use two forms of birth control (at least one of which must be a barrier
method) starting at Screening and throughout the study period and for 30
days after final study drug administration. Acceptable forms include:

1. Established use of oral, injected or implanted hormonal methods of
contraception;

2. Placement of an intrauterine device (IUD) or intrauterine system (IUS);

3. Barrier methods of contraception: Condom OR Occlusive cap (diaphragm or
cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.

- Female subject must not be breastfeeding at Screening or during the study period and
for 30 days after final study drug administration.

- Female subject must not donate ova starting at Screening and throughout the study
period and for 30 days after final study drug administration.

- Male subject and their female spouse/partners who are of childbearing potential must
be using highly effective contraception consisting of two forms of birth control (one
of which must be a barrier method) starting at Screening and continue throughout the
study period and for 30 days after final study drug administration. Acceptable forms
include:

1. Established use of oral, injected or implanted hormonal methods of contraception.

2. Placement of an intrauterine device (IUD) or intrauterine system (IUS).

3. Barrier methods of contraception: Condom OR Occlusive cap (diaphragm or
cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.

- Male subjects must not donate sperm starting at Screening and throughout the study
period and for at least 30 days after final study drug administration.

- Patients must provide written informed consent to participate in the study

- Patients may not have received chemotherapy for advanced NSCLC. Previous adjuvant
and/or neoadjuvant treatment for NSCLC is permitted

- Prior radiation therapy is permitted provided patients have recovered from the acute,
toxic effects of radiotherapy prior to randomization. A minimum of 28 days must have
elapsed between the end of radiotherapy and randomization

- Prior surgery is permitted provided that the surgery was done >= 28 days prior to
randomization and adequate wound healing has occurred prior to randomization

Exclusion Criteria:

- Prior exposure to agents directed at the Human Epidermal Receptor (HER) axis (eg,
erlotinib, gefitinib, and cetuximab)

- Prior insulin-like growth factor -1 receptor (IGF-1R) inhibitor therapy

- Malignancies other than NSCLC within the past 3 years (exceptions if curatively
treated; basal or squamous cell carcinoma of skin; locally advanced prostate cancer;
ductal carcinoma in situ of breast; in situ cervical carcinoma; and superficial
bladder cancer)

- Diabetes mellitus currently requiring insulinotropic or insulin therapy

- Use of proton pump inhibitors such as omeprazole within 14 days prior to
randomization. H2-receptor antagonists such as ranitidine are not excluded

- Symptomatic brain metastases that are not stable, require steroids, or have required
radiation and/or other related treatment (i.e., anti-epileptic medication) within 21
days prior to randomization

- Participated in any interventional clinical study or has been treated with any
investigational drugs within 30 days or 5 half lives whichever is longer, prior to the
initiation of Screening or during the course of the study.

- History of poorly controlled gastrointestinal disorders that could affect the
absorption of study drug (eg, Crohn's disease or ulcerative colitis)

- History (within last 6 months) of significant cardiovascular disease unless the
disease is well-controlled. Significant cardiac disease includes second/third degree
heart block; clinically significant ischemic heart disease; superior vena cava (SVC)
syndrome; poorly controlled hypertension; congestive heart failure of New York Heart
Association (NYHA) Class II or worse (slight limitation of physical activity;
comfortable at rest, but no ordinary physical activity results in fatigue,
palpitation, or dyspnea)

- History of arrhythmia (multifocal premature ventricular contractions [PVCs], bigeminy,
trigeminy, ventricular tachycardia, or uncontrolled atrial fibrillation) that is
symptomatic or requires treatment (>= grade 3), left bundle branch block (LBBB), or
asymptomatic sustained ventricular tachycardia are not allowed. Patients with atrial
fibrillation controlled by medication are not excluded

- Mean QTcF interval >= 450 msec at screening

- Use of drugs that have a known risk of causing Torsades de Pointes (TdP) ('Torsades
List' on www.azcert.org/medical-pros/drug-lists/bycategory.cfm) are prohibited within
14 days prior to randomization

- Use of strong/moderate CYP1A2 inhibitors such as ciprofloxacin and fluvoxamine. Other
less potent CYP1A2 inhibitors/inducers are not excluded

- Use of strong/moderate CYP3A4 inhibitors and inducers

- History of cerebrovascular accident (CVA) within 6 months prior to randomization or
that resulted in ongoing neurologic instability

- History of any psychiatric or neurologic condition that might impair the patient's
ability to understand or to comply with the requirements of the study or to provide
informed consent

- Pregnant or breast-feeding females

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to the study drug

- Active infection, serious underlying medical condition (including any type of active
seizure disorder within 12 months prior to randomization), symptomatic brain
metastases, or serious chronic illness that would impair the ability of the patient to
receive study drug