Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Other Indications, Brain Cancer, Neurology |
| Therapuetic Areas: | Neurology, Oncology, Other |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/5/2019 |
| Start Date: | September 22, 2010 |
| End Date: | June 3, 2015 |
Using Positron Emission Tomography (PET) to Predict Intracranial Tumor Growth in Neurofibromatosis Type II (NF2) Patients
Background:
- Neurofibromatosis type II (NF2) is associated with tumors of the nerves, brain, and
spinal cord. Most people with NF2 develop vestibular schwannomas, or tumors on the
hearing and balance nerves. As they grow, vestibular schwannomas can cause hearing loss
and balance problems. If they grow very large they can cause more serious problems, such
as seizures, loss of eyesight, weakness, speech problems, and problems with the sense of
touch. More research is needed into NF2 because researchers do not completely understand
why these tumors occur or what makes them grow over time.
- Currently, tumor size is measured with magnetic resonance imaging (MRI) scans. However,
MRI scans cannot predict how fast a tumor will grow. By using positron emission
tomography (PET) scanning, researchers hope to be able to predict sudden growth spurts
of tumors associated with NF2 and develop better treatment methods for this type of
cancer.
Objectives:
- To use magnetic resonance imaging and positron emission tomography to better understand the
growth of brain tumors in people with neurofibromatosis type II.
Eligibility:
- Individuals between 18 and 50 years of age who have been diagnosed with NF2 and have at
least three untreated intracranial tumors.
Design:
- This study requires an initial set of outpatient visits to the NIH Clinical Center that
will last 7 to 10 days.
- Participants will have a physical and neurological examination and blood tests at the
first visit. Participants will then have the following imaging studies to examine the
tumors:
- MRI scans of the brain
- PET scans of the brain, combined with a computed tomography (CT) scan. The PET scans
will be performed on separate days. Different contrast agents will be used for both
scans, so researchers will inform participants if they need to fast or follow other
procedures before having the scan.
- After the initial imaging studies, participants will have additional MRI scans every 6
months for 2 years to track tumor growth.
- Neurofibromatosis type II (NF2) is associated with tumors of the nerves, brain, and
spinal cord. Most people with NF2 develop vestibular schwannomas, or tumors on the
hearing and balance nerves. As they grow, vestibular schwannomas can cause hearing loss
and balance problems. If they grow very large they can cause more serious problems, such
as seizures, loss of eyesight, weakness, speech problems, and problems with the sense of
touch. More research is needed into NF2 because researchers do not completely understand
why these tumors occur or what makes them grow over time.
- Currently, tumor size is measured with magnetic resonance imaging (MRI) scans. However,
MRI scans cannot predict how fast a tumor will grow. By using positron emission
tomography (PET) scanning, researchers hope to be able to predict sudden growth spurts
of tumors associated with NF2 and develop better treatment methods for this type of
cancer.
Objectives:
- To use magnetic resonance imaging and positron emission tomography to better understand the
growth of brain tumors in people with neurofibromatosis type II.
Eligibility:
- Individuals between 18 and 50 years of age who have been diagnosed with NF2 and have at
least three untreated intracranial tumors.
Design:
- This study requires an initial set of outpatient visits to the NIH Clinical Center that
will last 7 to 10 days.
- Participants will have a physical and neurological examination and blood tests at the
first visit. Participants will then have the following imaging studies to examine the
tumors:
- MRI scans of the brain
- PET scans of the brain, combined with a computed tomography (CT) scan. The PET scans
will be performed on separate days. Different contrast agents will be used for both
scans, so researchers will inform participants if they need to fast or follow other
procedures before having the scan.
- After the initial imaging studies, participants will have additional MRI scans every 6
months for 2 years to track tumor growth.
OBJECTIVE:
The objective of this prospective observational study of intracranial tumors in patients with
neurofibromatosis type 2 (NF2) is to gain insight into the use of 18F-fluoro-deoxyglucose
(FDG) and 3 -deoxy-3 -18F-fluorothymidine (FLT) positron emission tomography (PET)/computed
tomography (CT) as a predictive measure of future tumor growth patterns.
STUDY POPULATION:
Twelve patients, ages 18-50, with a clinical or genetic diagnosis of NF2 and harboring at
least 3 unoperated intracranial tumors (meningiomas and/or vestibular schwannomas) will
participate in this study.
DESIGN:
Study participants will be evaluated with a thorough physical and neurologic examination upon
enrollment. This initial outpatient evaluation will include contrast-enhanced magnetic
resonance imaging (MRI) of the brain, FDG-PET/CT and FLT-PET/CT scans.
Subjects will be followed as outpatients for two years, during which time MRI evaluation will
be performed every six months.
OUTCOME MEASURES:
Based on data derived from this study, we hope to correlate FDG-PET/CT and FLT-PET/CT scans
with metabolic activity and cellular proliferation within tumors. These findings will help us
better forecast tumor growth and senescence. These findings should permit the safer treatment
of the subset of tumors that will grow and cause symptoms and avoid the unnecessary treatment
of lesions that will remain stable (not requiring treatment) in these patients.
The objective of this prospective observational study of intracranial tumors in patients with
neurofibromatosis type 2 (NF2) is to gain insight into the use of 18F-fluoro-deoxyglucose
(FDG) and 3 -deoxy-3 -18F-fluorothymidine (FLT) positron emission tomography (PET)/computed
tomography (CT) as a predictive measure of future tumor growth patterns.
STUDY POPULATION:
Twelve patients, ages 18-50, with a clinical or genetic diagnosis of NF2 and harboring at
least 3 unoperated intracranial tumors (meningiomas and/or vestibular schwannomas) will
participate in this study.
DESIGN:
Study participants will be evaluated with a thorough physical and neurologic examination upon
enrollment. This initial outpatient evaluation will include contrast-enhanced magnetic
resonance imaging (MRI) of the brain, FDG-PET/CT and FLT-PET/CT scans.
Subjects will be followed as outpatients for two years, during which time MRI evaluation will
be performed every six months.
OUTCOME MEASURES:
Based on data derived from this study, we hope to correlate FDG-PET/CT and FLT-PET/CT scans
with metabolic activity and cellular proliferation within tumors. These findings will help us
better forecast tumor growth and senescence. These findings should permit the safer treatment
of the subset of tumors that will grow and cause symptoms and avoid the unnecessary treatment
of lesions that will remain stable (not requiring treatment) in these patients.
- INCLUSION CRITERIA:
- Clinical diagnosis of NF2 by established clinical criteria or genetic testing.
- Age 18 to 50.
- A minimum of 3 intracranial tumors (meningiomas and/or VSs) measuring = or > 1cm in
size, including:
1. At least one unoperated VS > 1 cm in size AND
2. At least one unoperated meningioma > 1 cm in size
- No pregnancy or intent to become pregnant, with proper use of contraception for the
duration of the study.
- Normal liver enzymes: tests should be completed within 14 days before injection of the
radiopharmaceutical; SGOT, SGPT <5x ULN; bilirubin less than or equal to 2x ULN
- If prior radiation therapy to the tumor: >2 years must have passed after radiotherapy
administration and tumor must demonstrate growth after radiotherapy (signifying a
viable tumor for study is present)
- If prior chemotherapy: must have completed chemotherapy >6 months prior to enrollment
to allow washout of chemotherapeutic agent
EXCLUSION CRITERIA:
- Clinically unstable condition that precludes serial clinical and imaging evaluation
(i.e. Class 3 congestive heart failure, severe chronic renal insufficiency, severe
chronic obstructive pulmonary disease).
- Contraindication to MRI scanning, including pacemakers or other implanted electrical
devices, brain stimulators, some types of dental implants, aneurysm clips (metal clips
on the wall of a large artery), metallic prostheses (including metal pins and rods,
heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, or
shrapnel fragments
- Severe chronic renal insufficiency (glomerular filtration rate < 30 mL/min/1.73 m2),
hepatorenal syndrome or post-liver transplantation.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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