Clinical Study to Explore the Efficacy of ACT-129968 in Patients With Partly Controlled Asthma

Inclusion Criteria:

- Signed informed consent prior to any study-mandated procedure

- Males and females age 18 to 65 years

- Women of childbearing potential must use adequate contraception

- Presenting with a diagnosis of asthma according to GINA Guidelines

- Pre-bronchodilator forced expiratory volume in one second (FEV1) < / = 85% of
patient's predicted normal value

- Reversibility of airway obstruction of > / = 12% and > / = 200mL from
pre-bronchodilator FEV1

- ACQ score > / = 1.5

Exclusion Criteria:

- History of life-threatening asthma

- Any asthma exacerbation requiring treatment with systemic corticosteroids within the
last 3 months

- Ongoing or recent treatment with medication for allergic airway disease

- Smoking within the last year, or life-time consumption > / = 10 pack-years (e.g., 20
cigarettes/day for 10 years)

- History of chronic pulmonary disease (other than asthma), such as chronic obstructive
pulmonary disease (COPD), fibrosis, tuberculosis or sarcoidosis

- Pregnant or lactating women

- Diagnosis of aspirin or non-steroidal anti-inflammatory drug (NSAID)-induced asthma

- Any hospital admission for asthma within the last 6 months

- Anti-IgE therapy at any time check/update interventions by explicitely writing the
experimental drug dosage in the interventions description

- Any circumstances or conditions, which, in the opinion of the investigator, may affect
full participation in the study or compliance with the protocol