Ceftriaxone in Non-neutropenic Fever



Status:Completed
Conditions:Cancer, Cancer, Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases, Oncology
Healthy:No
Age Range:Any - 22
Updated:5/27/2013
Start Date:August 2010
End Date:December 2010
Contact:adam esbenshade, M.D., M.S.C.I
Email:adam.esbenshade@vanderbilt.edu
Phone:615-936-1762

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This is a retrospective chart review of all patients cared for at Monroe Carell Jr.
Children's Hospital at Vanderbilt including the following:

- patients between 2007-2009 with malignancy, Langerhans cell histiocytosis (LCH) or
hemophagocytic lymphohistiocytosis (HLH) and a central venous catheter who were under
23 years of age at time of diagnosis in order to ascertain the associated symptoms,
management and outcome of all episodes of non-neutropenic fever.

- to identify a subset of low-risk patients that can be safely managed without use of
empiric antibiotics.


Inclusion Criteria:

- Diagnosed with malignancy, Langerhans cell histiocytosis,or hemophagocytic
lymphohistiocytosis from 2007 through 2009

- Under 23 years at time of diagnosis of malignancy, Langerhans cell histiocytosis,or
hemophagocytic lymphohistiocytosis

- Treated at Monroe Carell Jr. Children's Hospital at Vanderbilt for aforementioned
diagnosis from 2007 through 2010

- While on immunosuppressive therapy with a central venous line in place had at least
one documented episode of fever (defined as ≥ 38.0°Celsius orally for over 30 minutes
or ≥ 38.3°Celsius orally x1).

Exclusion Criteria:

- Does not meet all inclusion criteria as stated above
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