Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Early Alzheimer's Disease
Status: | Completed |
---|---|
Conditions: | Alzheimer Disease |
Therapuetic Areas: | Neurology |
Healthy: | No |
Age Range: | 50 - 80 |
Updated: | 4/21/2016 |
Start Date: | February 2011 |
End Date: | February 2014 |
A Phase 2, Multicenter, 24-month, Randomized, Third-party Unblinded, Placebo-controlled, Parallel-group Amyloid Imaging Positron Emission Tomography (Pet) And Safety Trial Of Acc-001 And Qs-21 Adjuvant In Subjects With Early Alzheimer's Disease.
This study in individuals with early Alzheimer's disease is designed to assess:(1) safety
and tolerability (2) the capacity of ACC-001 and QS-21 adjuvant to reduce brain amyloid load
as measured by positron emission tomography (PET) scans.
and tolerability (2) the capacity of ACC-001 and QS-21 adjuvant to reduce brain amyloid load
as measured by positron emission tomography (PET) scans.
Inclusion Criteria:
- Concern about a change in cognition expressed by the subject or by an informant that
knows the subject well
- Mini-Mental State Examination (MMSE) score ≥ 25
- Global Clinical Dementia Rating = 0.5.
- General cognition and functional performance sufficiently preserved such that a
diagnosis of Alzheimer's dementia cannot not be made by the site physician at the
time of screening.
- Amyloid burden detected on screening brain PET scan.
- Other inclusion criteria apply.
Exclusion Criteria:
- Significant neurological disease other than early Alzheimer's disease
- Major psychiatric disorder or symptom
- Contraindication to undergo brain MRI
- Unstable medical conditions
- Other exclusion criteria apply
We found this trial at
40
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Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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Butler Hospital Founded in 1844, Butler Hospital is the state's only non-profit, free-standing psychiatric hospital...
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3800 Reservoir Rd NW
Washington, District of Columbia 20007
Washington, District of Columbia 20007
(202) 444-2000
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Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
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