Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Early Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 80
Updated:4/21/2016
Start Date:February 2011
End Date:February 2014

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A Phase 2, Multicenter, 24-month, Randomized, Third-party Unblinded, Placebo-controlled, Parallel-group Amyloid Imaging Positron Emission Tomography (Pet) And Safety Trial Of Acc-001 And Qs-21 Adjuvant In Subjects With Early Alzheimer's Disease.

This study in individuals with early Alzheimer's disease is designed to assess:(1) safety
and tolerability (2) the capacity of ACC-001 and QS-21 adjuvant to reduce brain amyloid load
as measured by positron emission tomography (PET) scans.


Inclusion Criteria:

- Concern about a change in cognition expressed by the subject or by an informant that
knows the subject well

- Mini-Mental State Examination (MMSE) score ≥ 25

- Global Clinical Dementia Rating = 0.5.

- General cognition and functional performance sufficiently preserved such that a
diagnosis of Alzheimer's dementia cannot not be made by the site physician at the
time of screening.

- Amyloid burden detected on screening brain PET scan.

- Other inclusion criteria apply.

Exclusion Criteria:

- Significant neurological disease other than early Alzheimer's disease

- Major psychiatric disorder or symptom

- Contraindication to undergo brain MRI

- Unstable medical conditions

- Other exclusion criteria apply
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Fort Myers, FL
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
643
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Boston, MA
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5860 N. La Cholla Blvd.
Tucson, Arizona 85704
520-742-1833
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Bennington, Vermont 05201
546
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Bennington, VT
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Bennington, Vermont
547
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Boston, Massachusetts 02114
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Brooksville, Florida
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Brooksville, FL
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Clifton Park, New York 12065
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East Providence, Rhode Island 02914
621
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East Providence, RI
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474
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Eatontown, NJ
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Fort Myers, Florida 33907
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Fort Myers, Florida 33919
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Houston, TX
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Las Vegas, NV
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Las Vegas, Nevada 89128
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Las Vegas, Nevada 89135
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Miami, Florida 33137
990
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Miami, FL
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Miami Beach, Florida 33140
991
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New Haven, Connecticut 06510
537
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New Haven, Connecticut 06511
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New Haven, Connecticut 06519
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Emile St
Omaha, Nebraska 68198
(402) 559-4000
Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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Oxnard, CA
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Phoenix, Arizona 85006
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Phoenix, Arizona 85006
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345 Blackstone Blvd
Providence, Rhode Island 02906
(401) 455-6200
Butler Hospital Founded in 1844, Butler Hospital is the state's only non-profit, free-standing psychiatric hospital...
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Sun City, Arizona 85351
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Sun City, Arizona 85351
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Sun City, Arizona 85351
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Tucson, Arizona 85719
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Tucson, Arizona 85724
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Tucson, Arizona 85741
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Washington, District of Columbia 20007
325
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Washington,
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3800 Reservoir Rd NW
Washington, District of Columbia 20007
(202) 444-2000
Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
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Washington, District of Columbia 20057
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West Palm Beach, FL
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