The Effect of Exercise Training on Skeletal Muscle Metabolism in Peripheral Artery Disease (PAD)



Status:Completed
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:40 - Any
Updated:4/2/2016
Start Date:October 2010
End Date:June 2014
Contact:Jessica Milian, BA
Email:jmilian@partners.org
Phone:617-732-6320

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Trial Summary
Trial Overview
Inclusion Criteria

The Effect of Exercise Training on Skeletal Muscle Metabolism in Peripheral Artery Disease

Specific Aim 1: To test the hypothesis that subjects with PAD and intermittent claudication
have altered expression of genes that regulate skeletal muscle metabolism.

Specific Aim 2: To test the hypothesis that exercise training improves calf skeletal muscle
insulin resistance and genes that regulate skeletal muscle metabolic function in PAD
patients with intermittent claudication.


Inclusion Criteria:

- claudication symptoms

- ABI ≤ 0.9 in the symptomatic leg

Exclusion Criteria:

- diabetes

- impaired fasting glucose

- peripheral vascular intervention within the prior six months

- recent unstable angina

- myocardial infarction or stroke within the prior six months

- changes to their HMG-CoA reductase inhibitor (statin)within the past three months

- changes to pentoxifylline and/or cilostazol regimen within the past three months or
anticipated to be necessary during the study

- are on Coumadin

- exercise limitations for reasons other than intermittent claudication (such as
congestive heart failure, angina, chronic lung disease, or other disorders affecting
the limb such as arthritis or neuropathy)

- rest pain or ulcers due to critical limb ischemia

- lower extremity amputation
We found this trial at
1
site
Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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