A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy



Status:Terminated
Conditions:Lymphoma, Psychiatric
Therapuetic Areas:Oncology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:1/10/2019
Start Date:April 4, 2011
End Date:March 28, 2014

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Trial Summary
Trial Overview
Inclusion Criteria

AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF INOTUZUMAB OZOGAMICIN ADMINISTERED IN COMBINATION WITH RITUXIMAB COMPARED TO DEFINED INVESTIGATOR'S CHOICE THERAPY IN SUBJECTS WITH RELAPSED OR REFRACTORY CD22-POSITIVE AGGRESSIVE NON-HODGKIN LYMPHOMA WHO ARE NOT CANDIDATES FOR INTENSIVE HIGH-DOSE CHEMOTHERAPY

The purpose of this study is to evaluate the efficacy of inotuzumab ozogamicin plus rituximab
in relapsed/refractory aggressive Non-Hodgkin lymphoma patients who are not candidates for
intensive high-dose chemotherapy. Specifically, the goal is to demonstrate the superiority of
this combination compared with an active comparator arm (investigator's choice of
rituximab+bendamustine or rituximab+gemcitabine) using the primary endpoint of overall
survival.


Inclusion Criteria:

Exclusion Criteria:
We found this trial at
78
sites
Baylor University Medical Center
3500 Gaston Avenue
Dallas, Texas 75246
1.800.422.9567
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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Barbara Ann Karmanos Cancer Institute
4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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Detroit, MI
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Shands Hospital at the University of Florida
Gainesville, Florida 32610
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Gainesville, FL
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Baptist Medical Center
Jacksonville, Florida 32207
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Jacksonville, FL
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Advanced Medical Specialties
8940 N Kendall Dr # 300E
Miami, Florida 33176
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Miami, FL
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Beth Israel Med Ctr
305 1st Avenue # Dazian 7
New York, New York 10003
(212) 420-2806
Beth Israel Med Ctr The physicians and staff of Mount Sinai Beth Israel's Heart Institute...
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New York, NY
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St Luke's - Roosevelt Hospital Center
1111 Amsterdam Ave
New York, New York 10025
(212) 523-4000
St Luke's - Roosevelt Hospital Center With 523 beds, Mount Sinai St. Luke's serves as...
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New York, NY
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Georgia Regents Medical Cancer Pharmacy
Augusta, Georgia 30912
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Augusta, GA
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Augusta University
1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
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Augusta, GA
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Mount Sinai Comprehensive Cancer Center, Aventura
Aventura, Florida 33180
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Aventura, FL
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University Cancer Institute, LLC
Boynton Beach, Florida 33426
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Boynton Beach, FL
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Disney Family Cancer Center at Providence St Joseph Medical Center
Burbank, California 91505
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Burbank, CA
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Providence St. Joseph Medical Center
Burbank, California 91505
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The University Hospital
Cincinnati, Ohio 45219
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Cincinnati, OH
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Kootenai Cancer Center
Coeur d'Alene, Idaho 83814
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Coeur d'Alene, ID
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Good Samaritan Hospital, Corvallis
Corvallis, Oregon 97330
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Corvallis, OR
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Samaritan Ambulatory Infusion Services
Corvallis, Oregon 97330
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Corvallis, OR
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University Hospital - St. Paul
Dallas, Texas 75235
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University Hospital - Zale Lipshy
Dallas, Texas 75235
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Baylor Charles A Sammons Cancer Center
Dallas, Texas 75246
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Simmons Comprehensive Cancer Center
Dallas, Texas 75390
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Decatur Memorial Hospital (DMH)
Decatur, Illinois 62526
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Decatur, IL
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Barbara Ann Karmanos Cancer Institute at farmington Hills
Farmington Hills, Michigan 48334
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Farmington Hills, MI
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21st Century Oncology of Jacksonville, LLC
Fernandina Beach, Florida 32034
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Fernandina Beach, FL
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Hematology-Oncology Medical Group of Fresno Inc
Fresno, California 93720
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Fresno, CA
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Davis Cancer Pavilion and Shands Medical Plaza
Gainesville, Florida 32608
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Gainesville, FL
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Shands Cancer Hospital at the University of Florida
Gainesville, Florida 32608
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Gainesville, FL
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UF Health Davis Cancer Pavillion and Shands Med Plaza
Gainesville, Florida 32608
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UF Health Shands Cancer Hospital
Gainesville, Florida 32608
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UF Health Shands Hospital
Gainesville, Florida 32610
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Penn State Milton S. Hershey Medical Center
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Houston, TX
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21st Century Oncology of Jacksonville, Inc.
Jacksonville, Florida 32034
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Jacksonville, FL
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Baptist Cancer Institute
Jacksonville, Florida
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Jacksonville, FL
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University of Kansas Medical Center
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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Thompson Oncology Group
1915 White Avenue
Knoxville, Tennessee 37916
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Knoxville, TN
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Medical Specialists Of Palm Beaches
Lake Worth, Florida 33467
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Lake Worth, FL
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Universitaire Ziekenhuizen Leuven
Leuven, Vlaams Brabant
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Leuven,
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University of Kentucky A.B. Chandler Medical Center
Lexington, Kentucky 40536
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Lexington, KY
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University of Kentucky, Markey Cancer Center
Lexington, Kentucky
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Lexington, KY
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Southeast Nebraska Hematology & Oncology Consultants, P.C. d/b/a Southeast Nebraska Cancer Center
Lincoln, Nebraska 68510
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Lincoln, NE
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Ronald Reagan UCLA Medical Center, Drug Information Center, Department of Pharmaceutical Services
Los Angeles, California 90095
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Los Angeles, CA
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Clinical Research Unit
Los Angeles, California 90024
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Peter Morton Medical Plaza
Los Angeles, California 90095
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Los Angeles, CA
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Ronald Reagan UCLA Medical Center
Los Angeles, California 90095
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Los Angeles, CA
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Thompson Oncology Group
Maryville, Tennessee 37804
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Maryville, TN
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Mercy Hospital
Miami, Florida 33133
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Miami, FL
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Mercy Research Institute
Miami, Florida
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida 33140
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Miami Beach, FL
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Mount Sinai Medical Center
Miami Beach, Florida 33140
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Floyd Memorial Cancer Center of Indiana
New Albany, Indiana 47150
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New Albany, IN
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Tulane University Hospital & Clinic
New Orleans, Louisiana 70112
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New Orleans, LA
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Beth Israel Comprehensive Cancer Center
New York, New York
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New York, NY
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Samaritan Pacific Coast Hospital
Newport, Oregon 97365
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Newport, OR
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OU Medical Center Presbyterian Professional Building
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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OU Medical Center Presbyterian Tower
Oklahoma City, Oklahoma 73104
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Peggy and Charles Stephenson Cancer Center (chemo & infusion)
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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Peggy and Charles Stephenson Cancer Center (clinic location)
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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21st Century Oncology of Jacksonville, LLC
Orange Park, Florida 32073
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Orange Park, FL
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Kootenai Cancer Center
Post Falls, Idaho 83854
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Post Falls, ID
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Barnes Jewish Hospital
Saint Louis, Missouri 63110
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Saint Louis, MO
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Washington University in St. Louis
Saint Louis, Missouri 63110
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Saint Louis, MO
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Washington University
Saint Louis, Missouri 63110
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Park Nicollet Frauenshuh Cancer Center
Saint Louis Park, Minnesota 55426
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Barnes-Jewish St. Peters
Saint Peters, Missouri 63376
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Sansum Clinic
Santa Barbara, California 93105
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Santa Barbara, CA
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UCLA Santa Monica Hematology-Oncology
Santa Monica, California 90404
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Santa Monica, CA
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Guthrie Clinic, Ltd.
Sayre, Pennsylvania 18840
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Sayre, PA
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Robert Packer Hospital
Sayre, Pennsylvania 18840
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Sayre, PA
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Thompson Oncology Group
Sevierville, Tennessee 37862
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Sevierville, TN
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Sansum Clinic
Solvang, California 93463
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Solvang, CA
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Stony Brook University Medical Center Cancer Center
Stony Brook, New York 11794
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Stony Brook, NY
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Stony Brook University Medical Center
101 Nicolls Rd
Stony Brook, New York 11794
(631) 444-4000
Stony Brook University Medical Center Stony Brook Medicine expresses our shared mission of research, clinical...
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Stony Brook, NY
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Howard University Hospital
Washington, District of Columbia 20060
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Washington,
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West Chester Hospital Medical Building
West Chester, Ohio 45069
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West Chester, OH
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University of Kansas Cancer Center and Medical Pavilion
Westwood, Kansas 66205
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Westwood, KS
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