A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy



Status:Terminated
Conditions:Lymphoma, Psychiatric
Therapuetic Areas:Oncology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:1/10/2019
Start Date:April 4, 2011
End Date:March 28, 2014

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Trial Summary
Trial Overview
Inclusion Criteria

AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF INOTUZUMAB OZOGAMICIN ADMINISTERED IN COMBINATION WITH RITUXIMAB COMPARED TO DEFINED INVESTIGATOR'S CHOICE THERAPY IN SUBJECTS WITH RELAPSED OR REFRACTORY CD22-POSITIVE AGGRESSIVE NON-HODGKIN LYMPHOMA WHO ARE NOT CANDIDATES FOR INTENSIVE HIGH-DOSE CHEMOTHERAPY

The purpose of this study is to evaluate the efficacy of inotuzumab ozogamicin plus rituximab
in relapsed/refractory aggressive Non-Hodgkin lymphoma patients who are not candidates for
intensive high-dose chemotherapy. Specifically, the goal is to demonstrate the superiority of
this combination compared with an active comparator arm (investigator's choice of
rituximab+bendamustine or rituximab+gemcitabine) using the primary endpoint of overall
survival.


Inclusion Criteria:

Exclusion Criteria:
We found this trial at
78
sites
University of Kansas Medical Center
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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Baylor University Medical Center
3500 Gaston Avenue
Dallas, Texas 75246
1.800.422.9567
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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Dallas, TX
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Barbara Ann Karmanos Cancer Institute
4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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Detroit, MI
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Shands Hospital at the University of Florida
Gainesville, Florida 32610
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Gainesville, FL
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Baptist Medical Center
Jacksonville, Florida 32207
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Jacksonville, FL
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Advanced Medical Specialties
8940 N Kendall Dr # 300E
Miami, Florida 33176
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Miami, FL
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Beth Israel Med Ctr
305 1st Avenue # Dazian 7
New York, New York 10003
(212) 420-2806
Beth Israel Med Ctr The physicians and staff of Mount Sinai Beth Israel's Heart Institute...
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New York, NY
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St Luke's - Roosevelt Hospital Center
1111 Amsterdam Ave
New York, New York 10025
(212) 523-4000
St Luke's - Roosevelt Hospital Center With 523 beds, Mount Sinai St. Luke's serves as...
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New York, NY
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Georgia Regents Medical Cancer Pharmacy
Augusta, Georgia 30912
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Augusta, GA
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Augusta University
1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
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Augusta, GA
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Mount Sinai Comprehensive Cancer Center, Aventura
Aventura, Florida 33180
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Aventura, FL
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University Cancer Institute, LLC
Boynton Beach, Florida 33426
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Boynton Beach, FL
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Disney Family Cancer Center at Providence St Joseph Medical Center
Burbank, California 91505
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Burbank, CA
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Providence St. Joseph Medical Center
Burbank, California 91505
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Burbank, CA
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The University Hospital
Cincinnati, Ohio 45219
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Cincinnati, OH
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Kootenai Cancer Center
Coeur d'Alene, Idaho 83814
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Coeur d'Alene, ID
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Good Samaritan Hospital, Corvallis
Corvallis, Oregon 97330
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Corvallis, OR
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Samaritan Ambulatory Infusion Services
Corvallis, Oregon 97330
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Corvallis, OR
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University Hospital - St. Paul
Dallas, Texas 75235
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University Hospital - Zale Lipshy
Dallas, Texas 75235
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Baylor Charles A Sammons Cancer Center
Dallas, Texas 75246
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Simmons Comprehensive Cancer Center
Dallas, Texas 75390
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Decatur Memorial Hospital (DMH)
Decatur, Illinois 62526
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Decatur, IL
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Barbara Ann Karmanos Cancer Institute at farmington Hills
Farmington Hills, Michigan 48334
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Farmington Hills, MI
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21st Century Oncology of Jacksonville, LLC
Fernandina Beach, Florida 32034
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Fernandina Beach, FL
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Hematology-Oncology Medical Group of Fresno Inc
Fresno, California 93720
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Fresno, CA
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Davis Cancer Pavilion and Shands Medical Plaza
Gainesville, Florida 32608
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Gainesville, FL
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Shands Cancer Hospital at the University of Florida
Gainesville, Florida 32608
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Gainesville, FL
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UF Health Davis Cancer Pavillion and Shands Med Plaza
Gainesville, Florida 32608
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UF Health Shands Cancer Hospital
Gainesville, Florida 32608
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UF Health Shands Hospital
Gainesville, Florida 32610
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Penn State Milton S. Hershey Medical Center
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Houston, TX
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21st Century Oncology of Jacksonville, Inc.
Jacksonville, Florida 32034
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Jacksonville, FL
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Baptist Cancer Institute
Jacksonville, Florida
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Jacksonville, FL
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Thompson Oncology Group
1915 White Avenue
Knoxville, Tennessee 37916
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Knoxville, TN
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Medical Specialists Of Palm Beaches
Lake Worth, Florida 33467
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Lake Worth, FL
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Universitaire Ziekenhuizen Leuven
Leuven, Vlaams Brabant
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Leuven,
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University of Kentucky A.B. Chandler Medical Center
Lexington, Kentucky 40536
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Lexington, KY
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University of Kentucky, Markey Cancer Center
Lexington, Kentucky
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Lexington, KY
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Southeast Nebraska Hematology & Oncology Consultants, P.C. d/b/a Southeast Nebraska Cancer Center
Lincoln, Nebraska 68510
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Lincoln, NE
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Ronald Reagan UCLA Medical Center, Drug Information Center, Department of Pharmaceutical Services
Los Angeles, California 90095
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Los Angeles, CA
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Clinical Research Unit
Los Angeles, California 90024
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Peter Morton Medical Plaza
Los Angeles, California 90095
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Los Angeles, CA
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Ronald Reagan UCLA Medical Center
Los Angeles, California 90095
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Los Angeles, CA
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Thompson Oncology Group
Maryville, Tennessee 37804
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Maryville, TN
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Mercy Hospital
Miami, Florida 33133
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Miami, FL
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Mercy Research Institute
Miami, Florida
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Miami, FL
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida 33140
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Miami Beach, FL
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Mount Sinai Medical Center
Miami Beach, Florida 33140
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Miami Beach, FL
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Floyd Memorial Cancer Center of Indiana
New Albany, Indiana 47150
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New Albany, IN
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Tulane University Hospital & Clinic
New Orleans, Louisiana 70112
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New Orleans, LA
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Beth Israel Comprehensive Cancer Center
New York, New York
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New York, NY
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Samaritan Pacific Coast Hospital
Newport, Oregon 97365
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Newport, OR
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OU Medical Center Presbyterian Professional Building
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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OU Medical Center Presbyterian Tower
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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Peggy and Charles Stephenson Cancer Center (chemo & infusion)
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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Peggy and Charles Stephenson Cancer Center (clinic location)
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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21st Century Oncology of Jacksonville, LLC
Orange Park, Florida 32073
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Orange Park, FL
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Kootenai Cancer Center
Post Falls, Idaho 83854
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Post Falls, ID
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Barnes Jewish Hospital
Saint Louis, Missouri 63110
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Saint Louis, MO
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Washington University in St. Louis
Saint Louis, Missouri 63110
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Saint Louis, MO
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Washington University
Saint Louis, Missouri 63110
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Saint Louis, MO
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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Park Nicollet Frauenshuh Cancer Center
Saint Louis Park, Minnesota 55426
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Saint Louis Park, MN
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Barnes-Jewish St. Peters
Saint Peters, Missouri 63376
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Saint Peters, MO
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Sansum Clinic
Santa Barbara, California 93105
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Santa Barbara, CA
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UCLA Santa Monica Hematology-Oncology
Santa Monica, California 90404
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Santa Monica, CA
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Guthrie Clinic, Ltd.
Sayre, Pennsylvania 18840
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Sayre, PA
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Robert Packer Hospital
Sayre, Pennsylvania 18840
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Sayre, PA
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Thompson Oncology Group
Sevierville, Tennessee 37862
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Sevierville, TN
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Sansum Clinic
Solvang, California 93463
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Solvang, CA
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Stony Brook University Medical Center Cancer Center
Stony Brook, New York 11794
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Stony Brook, NY
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Stony Brook University Medical Center
101 Nicolls Rd
Stony Brook, New York 11794
(631) 444-4000
Stony Brook University Medical Center Stony Brook Medicine expresses our shared mission of research, clinical...
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Stony Brook, NY
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Howard University Hospital
Washington, District of Columbia 20060
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Washington,
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West Chester Hospital Medical Building
West Chester, Ohio 45069
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West Chester, OH
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University of Kansas Cancer Center and Medical Pavilion
Westwood, Kansas 66205
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Westwood, KS
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